Plant protection products, including insecticides, are important for global food production but can have adverse effects on nontarget organisms including bees. Historically, research investigating such effects has focused mainly on the honeybee (Apis mellifera), whereas less information is available for non-Apis bees. Consequently, a comprehensive hazard (sensitivity) assessment for the majority of bees is lacking, which in turn hinders accurate risk characterization and consequently bee protection. Interspecies sensitivity extrapolation based on body weight might be a way to improve the situation, but in the past such approaches often ignored the phylogenetic background of the species used, which in turn potentially reduces the robustness of such results. Published acute contact sensitivity data (median lethal dose per bee) of bees to insecticides, their body weight, and their phylogenetic background were used to build interspecies scaling models to predict bee sensitivity based on their weight. The results indicate that 1) bee body weight is a predictor of acute contact bee sensitivity to a range of insecticides, and 2) phylogeny (nonindependence of data points) needs to be considered in cross-species analysis, although it does not always confound the observed effects. Environ Toxicol Chem 2021;40:2044–2052. © 2021 SETAC

中文翻译：

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使用系统发育知情的种间尺度框架根据体重推断急性接触蜜蜂对杀虫剂的敏感性

植物保护产品，包括杀虫剂，对全球粮食生产很重要，但会对包括蜜蜂在内的非目标生物产生不利影响。从历史上看，调查此类影响的研究主要集中在蜜蜂（Apis mellifera）上，而非蜜蜂的可用信息较少蜜蜂。因此，缺乏对大多数蜜蜂的综合危害（敏感性）评估，这反过来又阻碍了准确的风险表征，从而阻碍了蜜蜂保护。基于体重的种间敏感性外推可能是改善这种情况的一种方法，但在过去，这种方法经常忽略所用物种的系统发育背景，这反过来又可能降低此类结果的稳健性。已发表的蜜蜂对杀虫剂、体重和系统发育背景的急性接触敏感性数据（每只蜜蜂的中位致死剂量）用于建立种间尺度模型，以根据体重预测蜜蜂敏感性。结果表明，1）蜜蜂体重是蜜蜂对一系列杀虫剂急性接触敏感性的预测因子，环境毒物化学2021；40:2044–2052。© 2021 SETAC