Borderline personality disorder (BPD) is a severe psychiatric disorder accompanied by multiple comorbidities. Neuroimaging studies have identified structural abnormalities in BPD with most findings pointing to gray matter volume reductions in the fronto-limbic network, although results remain inconsistent. Similar alterations were found in posttraumatic stress disorder (PTSD), a common comorbidity of BPD. Only a small number of studies have investigated structural differences in BPD patients regarding comorbid PTSD specifically and studies conducting additional surface analyses are scarce. We investigated structural differences in women with BPD with and without PTSD and non-patient controls. Automated voxel-based and region-based volumetric analyses were applied. Additionally, four surface-based measures were analyzed: cortical thickness, gyrification index, fractal dimension, and sulcus depth. Analyses did not identify cortical volume alterations in the fronto-limbic network. Instead, hypergyrification was detected in the right superior parietal cortex in BPD patients compared to non-patient controls. No distinction was revealed between BPD patients with and without PTSD. These findings underline the importance of a holistic investigation examining volumetric and surface measures as these might enhance the understanding of structural alterations in BPD.

交际型人格障碍（BPD）是一种严重的精神疾病，伴有多种合并症。神经影像学研究已经发现了BPD的结构异常，尽管结果仍然不一致，但大多数发现都指向额-边缘网络中的灰质体积减少。在创伤后应激障碍（PTSD）中发现了类似的改变，PTSD是BPD的常见合并症。仅有少数研究专门针对合并症PTSD调查了BPD患者的结构差异，而进行其他表面分析的研究却很少。我们调查了有或没有PTSD和非患者对照的BPD妇女的结构差异。应用了基于自动体素和基于区域的体积分析。此外，还分析了四种基于表面的测量方法：皮质厚度，回旋指数，分形维数和沟深。分析未发现额叶-边缘网络中的皮质体积改变。取而代之的是，与非患者对照组相比，BPD患者的右上顶叶皮层检测到了过度旋转。没有或没有PTSD的BPD患者之间没有区别。这些发现强调了进行体积和表面测量的整体调查的重要性，因为这些可能会增强对BPD结构改变的理解。