Two-dimensional (2D) transition-metal disulfides (TMS₂) are promising functional components to construct a large variety of sensing devices. The rational engineering on their interlayer structures has recently demonstrated the capability of modulating electronic configurations and optical properties toward benchmarking performance. In this review, representative efforts and progress made on interlayer-engineered TMS₂ sensors are comprehensively reviewed, focusing on the intrinsic relationship between interlayer chemistry and sensing behaviors. Briefly, effective strategies mainly including intercalation and exfoliation are expatiated for effective interlayer engineering, and thereby for feasible modulation on electronic and optical properties. And then, the characteristic electrochemical and optical sensing performances are summarized to highlight the key promotion via interlayer-engineering. Finally, a perspective on the future development of 2D TMS₂ is offered. The overall aim of this review is to shed some light on the exploration of emerging materials in sensing fields.

二维（2D）过渡金属二硫化物（TMS ₂）是有前途的功能组件，可构成各种各样的传感设备。最近对它们的夹层结构进行了合理的设计，证明了可以调节电子配置和光学性能以达到基准性能的能力。在这次审查中，在层间工程TMS ₂上的代表性工作和取得的进展对传感器进行了全面审查，重点是夹层化学和传感行为之间的内在联系。简要地，阐述了有效的策略，主要包括插层和剥离，以进行有效的层间工程设计，从而实现对电子和光学性质的可行调制。然后，总结了电化学和光学传感的特性，以强调通过层间工程技术的关键推广。最后，提供了有关2D TMS ₂未来发展的观点。这篇综述的总体目的是为传感领域新兴材料的探索提供一些启示。