The recycling and recovery of organic matter and nutrients from sewage sludge for application in agricultural soils is gaining interest, while the presence of pharmaceutically active compounds (PhACs) in this matrix may have a great impact on the environment and human health. The aim of this review paper is to outline recent research on the occurrence of PhACs and their metabolites in sewage treatment lines. A total of 32 classes of therapeutic groups including 180 PhACs and 45 metabolites have been included. In a first part, a summary of the analytical methods with a critical overview of the extraction and determination techniques, quality control issues and methodological challenges for their determination is included. Subsequently, the study gives a snapshot of the concentration levels and distribution patterns found in primary, secondary, digested (aerobically and anaerobically), dehydrated and composted sludge. Data have been systematically summarized and categorized according to matrix type, treatment processes available for PhAC degradation in sludge, and geographical areas. Our literature review showed that antimicrobials, antibiotics, non-steroidal anti-inflammatory drugs (NSAIDs), antidepressants and antidiabetics were the most abundant PhACs found in sludge matrices.Overall, attenuation of PhACs concentrations occurs during sludge stabilization, in particular during anaerobic digestion and composting. PhAC sorption onto sludge is strongly affected by the physicochemical properties, the sludge matrix and the operating and environmental conditions. Lastly, the paper discusses the impact of PhACs on sludge-amended agricultural land. The potential ecotoxicological risk associated with the presence of PhACs in amended soil is medium-low for most PhACs. The most critical compounds found in sludge-amended soil are ciprofloxacin, 17α-ethinylestradiol, 17β-estradiol, and triclocarban and triclosan.

从污水污泥中回收和回收有机物和养分以用于农业土壤的兴趣日益浓厚，而该基质中药物活性化合物（PhAC）的存在可能会对环境和人类健康产生重大影响。本文的目的是概述有关污水处理管线中PhAC及其代谢物的最新研究。总共包括32种治疗组，包括180种PhAC和45种代谢物。在第一部分中，概述了分析方法，并对提取和测定技术，质量控制问题以及测定方法的挑战性进行了严格概述。随后，该研究概述了一级，二级，消化（厌氧和厌氧），脱水并堆肥的污泥。数据已根据基质类型，可用于污泥中PhAC降解的处理过程以及地理区域进行了系统汇总和分类。我们的文献综述表明，抗菌素，抗生素，非甾体类抗炎药（NSAIDs），抗抑郁药和抗糖尿病药是污泥基质中最丰富的PhAC。总体而言，PhACs浓度的降低在污泥稳定化期间，特别是在厌氧消化和消化过程中发生。堆肥。PhAC在污泥上的吸附受到理化性质，污泥基质以及操作和环境条件的强烈影响。最后，本文讨论了PhAC对污泥改良农业用地的影响。对于大多数PhAC，与改良土壤中PhAC的存在相关的潜在生态毒理风险为中低。在污泥改良土壤中发现的最关键的化合物是环丙沙星，17α-炔雌醇，17β-雌二醇，三氯卡班和三氯生。