High-sucrose high-fat diets are one of the causes of malnutrition, and may induce metabolic alterations such as dyslipidemia, insulin resistance, and adipogenesis. The objective of this work was to investigate the possible protective effect of traditionally edible avocado creole peel (Persea americana Mill var. drymifolia) when consuming a high-sucrose and fat diet (HSFD). The experimental animal model included 21 male Wistar rats divided in three groups: the control group received a standard diet of purina®, the HSFD group received a high fat diet plus 30% sucrose in drinking water, and finally the HSFD + AP group received the HSFD diet supplemented with 200 mg/kg of avocado peel for 14 weeks. It was observed that alterations included higher cholesterol, glucose, insulin, fatty acids and TNF-α levels as well as lower HDL, and adiponectin. The addition of avocado peel reverted some of these effects, resulting in normal values of triglicerides, insulin and adiponectin, while attenuated the levels of total cholesterol. Liver weight of the group added with avocado peel was similar to the control group. The neuronal density in the hippocampal areas CA1 and dentate gyrus DC were lower in the high glucose fat group, while the ingestion of the avocado peel showed a neuroprotective effect. The avocado creole ingestion reverted or attenuated most of the metabolic effects caused by a high-sucrose fat diet which was attributed to the compounds detected by HPLC-MS and GC-MS that included bioactive polyphenols such as flavanol quercetin, flavanone naringenin, flavan 3-ol catechin, cyanidin 3-glucoside, pelargonidin 3-glucoside, pelargonidin 3-rhamnoside, hydroxydelphinidin, eugenol and estragole.

中文翻译：

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鳄梨克里奥尔皮改善 Wistar 大鼠模型中高蔗糖脂肪饮食引起的代谢改变

高糖高脂肪饮食是营养不良的原因之一，并可能诱发代谢改变，如血脂异常、胰岛素抵抗和脂肪生成。这项工作的目的是研究传统食用鳄梨克里奥尔果皮 (Persea americana Mill var. drymifolia) 在食用高蔗糖和脂肪饮食 (HSFD) 时可能产生的保护作用。实验动物模型包括21只雄性Wistar大鼠，分为三组：对照组接受purina®标准饮食，HSFD组接受高脂饮食加饮用水中30%的蔗糖，最后HSFD+AP组接受HSFD 饮食补充了 200 毫克/公斤的鳄梨皮，持续 14 周。据观察，改变包括更高的胆固醇、葡萄糖、胰岛素、脂肪酸和 TNF-α 水平以及更低的 HDL 和脂联素。添加鳄梨皮可以逆转其中一些影响，导致甘油三酯、胰岛素和脂联素的正常值，同时降低总胆固醇的水平。添加鳄梨皮的组的肝脏重量与对照组相似。高糖脂肪组海马区 CA1 和齿状回 DC 的神经元密度较低，而鳄梨皮的摄入则显示出神经保护作用。摄入鳄梨克里奥尔可以逆转或减弱由高蔗糖脂肪饮食引起的大部分代谢作用，这归因于 HPLC-MS 和 GC-MS 检测到的化合物，包括生物活性多酚，如黄烷醇槲皮素、黄烷酮柚皮素、黄烷 3- ol 儿茶素、花青素 3-葡萄糖苷、天竺葵素 3-葡萄糖苷、天竺葵素 3-鼠李糖苷、羟基飞燕草素、