Although the electrospinning technique has been devoted to promoting therapeutic purposes as a drug carrier, however, there are still many fundamental problems in this area. This work focuses on a comparison of various diameter polyethersulfone (PES) electrospun ultrafine fibers as antimicrobial materials. The fibrous morphology, antimicrobial agent distribution, thermally property, and biocompatibility evaluation of PES-based ultrafine fibers were systematically investigated. The results demonstrated that the PES-based ultrafine fibers were suitable as antimicrobial material. Furthermore, the drug release behavior and mechanism were studied through total immersion. The release mechanism was confirmed to Fickian diffusion. It was revealed that the drug max release amount (71.5%) and release rate (7.71) are the highest for the smallest diameter ultrafine fibers. Meanwhile, the antimicrobial activity of PES ultrafine fibers is also inversely correlated with the diameter of fiber. The electrospun PES fibers would control their release behavior through the diameter and have a potential application in the wound dressings, such as chronic osteomyelitis and exposure injury.

中文翻译：

---

不同直径超细纤维作为抗菌材料的释放特性

尽管静电纺丝技术作为药物载体一直致力于促进治疗目的，但该领域仍存在许多基本问题。这项工作的重点是比较各种直径的聚醚砜 (PES) 电纺超细纤维作为抗菌材料。系统研究了PES基超细纤维的纤维形态、抗菌剂分布、热性能和生物相容性评价。结果表明，PES基超细纤维适合作为抗菌材料。此外，通过完全浸入研究了药物的释放行为和机制。Fickian 扩散证实了释放机制。揭示药物最大释放量（71.5%）和释放率（7. 71) 为最高的为最小直径的超细纤维。同时，PES超细纤维的抗菌活性也与纤维直径呈负相关。电纺 PES 纤维将通过直径控制其释放行为，并在伤口敷料中具有潜在的应用，例如慢性骨髓炎和暴露损伤。