The brominated flame retardant bis(2-ethylhexyl)-3,4,5,6-tetrabromophthalate (TBPH) is used widely in consumer items including polyurethane foam used in furniture. Information on its bioaccumulation in aquatic species is limited. In the current study, sediment bioaccumulation tests with the oligochaete Lumbriculus variegatus were performed on a spiked natural sediment equilibrated for 14.5 months. Analysis showed the TBPH used to spike the sediment contained a small amount (0.046% by mass) of mono-(2-ethylhexyl)-3,4,5,6-tetrabromophthalate (TBMEHP), a potential biotransformation product of the parent chemical. Steady-state biota-sediment accumulation factors (BSAFs) of 0.254 and 1.50 (kg organic carbon/kg lipid) were derived for TBPH and TBMEHP, respectively. TBPH had biphasic elimination behavior where 94% of the body burden was depleted within the first 12 h of elimination (i.e., half-life of 1.2 h or less) and the remaining 6% eliminated very slowly thereafter (half-life of 15 days). There was little evidence for biotransformation of either chemical by L. variegatus. This investigation confirms the extremely hydrophobic behavior of TBPH and its impact on its bioavailability.

溴化阻燃剂双（2-乙基己基）-3,4,5,6-四溴邻苯二甲酸酯 (TBPH) 广泛用于消费品，包括家具中使用的聚氨酯泡沫塑料。关于其在水生物种中的生物蓄积性的信息有限。在目前的研究中，用寡毛纲Lumbriculus variegatus进行沉积物生物积累测试在平衡 14.5 个月的加标天然沉积物中进行。分析表明，用于添加沉积物的 TBPH 含有少量（按质量计 0.046%）单-(2-乙基己基)-3,4,5,6-四溴邻苯二甲酸酯 (TBMEHP)，这是母体化学品的潜在生物转化产物。TBPH 和 TBMEHP 的稳态生物沉积物积累因子 (BSAF) 分别为 0.254 和 1.50 (kg 有机碳/kg 脂质)。TBPH 具有双相消除行为，其中 94% 的身体负荷在消除的前 12 小时内被消耗（即半衰期为 1.2 小时或更短），其余 6% 的消除非常缓慢（半衰期为 15 天） . 几乎没有证据表明L. variegatus 对这两种化学物质进行生物转化。这项调查证实了 TBPH 的极度疏水行为及其对其生物利用度的影响。