Background

Family history of Major Depressive Disorder (MDD) is a robust predictor of MDD onset, especially in early adolescence. We examined the relationships between familial risk for depression and alterations to resting state functional connectivity (rsFC) within the default mode network (wDMN) and between the DMN and the left/right hippocampus (DMN-LHIPP/DMN-RHIPP) to the risk for early adolescent MDD onset.

Methods

We examined 9403 youth aged nine to eleven from the Adolescent Brain Cognitive Development study. Depressive symptoms were measured with the parent-reported Child Behavior Checklist. Both youth and their parents completed the Kiddie Schedule for Affective Disorders and Schizophrenia, which provided MDD diagnoses. A family history screen was administered to determine familial risk for depression. Youth underwent a resting state functional magnetic resonance imaging scan, providing us with rsFC data.

Results

Negative wDMN rsFC was associated with child-reported current depression, both child- and parent-reported past depression, and parent-reported current depressive symptoms. No difference was found in wDMN, DMN-LHIPP or DMN-RHIPP rsFC in children with or without familial risk for depression. Familial risk for depression interacted with wDMN rsFC in association with child-reported past MDD diagnosis and parent-reported current depressive symptoms.

Limitations

Information such as length of depressive episodes and age of onset of depression was not collected.

Conclusions

Altered wDMN rsFC in youth at familial risk for depression may be associated with increased risk for MDD onset in adolescence, but longitudinal studies are needed to test this hypothesis.

中文翻译：

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静息状态功能连通性和家族风险对青少年早期 MDD 的贡献：青少年大脑认知发展研究的结果

背景

重度抑郁症 (MDD) 家族史是 MDD 发作的有力预测因素，尤其是在青春期早期。我们检查了抑郁症的家族风险与默认模式网络 (wDMN) 内以及 DMN 与左/右海马体 (DMN-LHIPP/DMN-RHIPP) 之间的静息状态功能连接 (rsFC) 改变与抑郁症风险之间的关系。青少年早期 MDD 发病。

方法

我们从青少年大脑认知发展研究中检查了 9403 名 9 至 11 岁的青少年。使用父母报告的儿童行为检查表测量抑郁症状。青少年和他们的父母都完成了儿童情感障碍和精神分裂症时间表，该时间表提供了 MDD 诊断。进行家族史筛查以确定抑郁症的家族风险。青年接受了静息状态功能磁共振成像扫描，为我们提供了 rsFC 数据。

结果

阴性 wDMN rsFC 与儿童报告的当前抑郁症、儿童和父母报告的过去抑郁症以及父母报告的当前抑郁症状相关。在有或没有患抑郁症家族风险的儿童中，wDMN、DMN-LHIPP 或 DMN-RHIPP rsFC 没有发现差异。抑郁症的家族风险与 wDMN rsFC 相互作用，与儿童报告的过去 MDD 诊断和父母报告的当前抑郁症状相关。

限制

没有收集抑郁发作时间和抑郁发作年龄等信息。

结论

有家族抑郁风险的青年中改变的 wDMN rsFC 可能与青春期 MDD 发病风险增加有关，但需要纵向研究来检验这一假设。