There is consistent evidence from cross-sectional studies that smoking is positively associated with mental disorders. The research on the prospective association, however, is inconsistent. In the present study, we aimed to further increase the knowledge of this association by addressing several issues in the body of research. Data used were from a nationally representative, population-based cohort study among 18- to 64-year-olds at baseline. Compared with nonsmokers, smokers at baseline were significantly more likely to experience first incidence of any mood, anxiety, or substance use disorder at 3-year follow-up while controlling for a wide range of confounding factors. The association with incident mood and anxiety disorders was particularly high among heavy smokers. The dose-effect analyses on later substance use disorders showed unclear results, warranting further research. Additional analyses showed that results at 6-year follow-up were very similar, except for a weaker relationship between smoking and substance use disorders.

来自横断面研究的一致证据表明，吸烟与精神障碍呈正相关。但是，有关预期关联的研究并不一致。在当前的研究中，我们旨在通过解决研究主体中的几个问题来进一步增加这种关联的知识。所使用的数据来自全国代表性的基于人群的队列研究，该研究在18岁至64岁的基线人群中进行。与不吸烟者相比，基线时吸烟者在3年的随访中首次出现任何情绪，焦虑或物质使用障碍的可能性更高，同时控制了多种混杂因素。在重度吸烟者中，与突发事件情绪和焦虑症的相关性特别高。对后来的物质使用障碍的剂量效应分析显示不清楚的结果，有待进一步研究。进一步的分析表明，在6年的随访中结果非常相似，只是吸烟与药物滥用失调之间的关系较弱。