Darwin emphasized the intimate relationship between the brain and the heart over 150 years ago. Healthy aging is associated with significant changes in both the brain and the heart. The changes between these, the two most important organs of the body, are linked via the vagus nerve. In this review, we examine the normative changes with aging and the effect that stress may have on how the brain–heart connection changes with age. We provide a framework based on the concept of neurovisceral integration and propose that stress regulation is emotion regulation. As such, studies that have investigated emotion regulation may yield insights into successful stress regulation that helps protect people from age-related decline. In addition, interventions that improve brain health also improve heart health and vice versa. We conclude by noting that significant sex and ethnic differences exist but that future studies are needed to more fully explicate how they may moderate the associations between stress and aging.

中文翻译：

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压力和衰老：神经内脏整合的观点

达尔文在 150 多年前就强调了大脑和心脏之间的密切关系。健康老龄化与大脑和心脏的显着变化有关。这些身体最重要的两个器官之间的变化通过迷走神经联系起来。在这篇综述中，我们研究了随着年龄增长的规范变化以及压力可能对大脑-心脏连接如何随年龄变化产生的影响。我们提供了一个基于神经内脏整合概念的框架，并提出压力调节就是情绪调节。因此，调查情绪调节的研究可能会为成功的压力调节提供见解，有助于保护人们免受与年龄相关的衰退。此外，改善大脑健康的干预措施也会改善心脏健康，反之亦然。