Bioconcentration of cedarwood oil constituents in rainbow trout,Environmental Science: Processes & Impacts

当前位置： X-MOL 学术 › Environ. Sci.: Processes Impacts › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Bioconcentration of cedarwood oil constituents in rainbow trout
Environmental Science: Processes & Impacts ( IF 4.3 ) Pub Date : 2021-3-11 , DOI: 10.1039/d1em00009h
Roxana Sühring _{1,

2,

3,

4} , Chang-Er Chen _{1,

2,

3,

4,

5} , Michael S. McLachlan _{1,

2,

3,

4} , Matthew MacLeod _{1,

2,

3,

4}

Affiliation

Cedarwood oil is an essential oil used as a fragrance material and insect repellent. Its main constituents are sesquiterpenes which are potentially bioaccumulative according to the REACH screening criteria. Cedarwood oil is a complex mixture of hydrophobic and volatile organic chemicals. The volatility and limited water solubility of its constituents are a challenge for standard bioconcentration factor (BCF) test methods using aqueous exposure. We used an abbreviated dietary exposure in vivo testing protocol with internal benchmark substances as “internal standards” to derive the BCF of cedarwood oil constituents using rainbow trout (Oncorhynchus mykiss). Internal benchmarking proved to be a useful tool to control for inter-individual variability, enabling us to calculate the BCF for all major cedarwood oil constituents as a mixture. We found that the BCF of two out of six analysed cedarwood oil constituents exceed a BCF of 5000 and two others exceed a BCF of 2000 (90% confidence level) even though we found evidence for biotransformation for individual constituents. The results of this study indicate that more work is warranted to study the bioaccumulation of essential oils and highlights the utility of internal benchmarking in in vivo dietary exposure BCF tests to increase robustness and allow for the BCF measurement of complex mixtures.

中文翻译：

虹鳟鱼中雪松油成分的生物浓缩

雪松油是用作香料和驱虫剂的香精油。其主要成分是倍半萜，根据REACH筛选标准，其可能具有生物蓄积性。雪松油是疏水性和挥发性有机化学物质的复杂混合物。其成分的挥发性和有限的水溶性是使用水暴露的标准生物浓缩因子（BCF）测试方法的挑战。我们使用了以内部基准物质作为“内部标准”的简化饮食暴露体内测试方案，以使用虹鳟鱼（Oncorhynchus mykiss）推导了雪松油成分的BCF。）。内部基准测试被证明是控制个体间变异的有用工具，使我们能够计算所有主要雪松油成分作为混合物的BCF。我们发现，六分之二的雪松油成分的BCF超过了5000的BCF，另外两个超过2000的BCF（90％的置信度），即使我们发现了单个成分发生生物转化的证据。这项研究的结果表明，有必要开展更多工作来研究精油的生物蓄积性，并着重指出内部基准测试在体内饮食暴露BCF测试中的作用，以提高耐用性并允许对复杂混合物进行BCF测量。

更新日期：2021-03-16

点击分享查看原文

点击收藏

阅读更多本刊最新论文