The fetal origins hypothesis suggests that health and nutrition shocks in utero are causally related to health deficits in old age. It has received considerable empirical support, both within epidemiology and economics but so far it has not been integrated into a life cycle theory of human aging and longevity. The present study shows that the health deficit model, based on the frailty index developed in gerontology, generates shock amplification consistent with the hypothesis. In order to discuss human health over the life cycle from conception to death, we develop a theory of ontogenetic growth and health in utero and during childhood, unify it with the health deficit model of adult aging, and discuss the transmission of early-life shocks to late-life health deficit accumulation.

中文翻译：

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胎儿起源——从受孕到死亡的健康和衰老的生命周期模型

胎儿起源假说表明，子宫内的健康和营养冲击与老年时的健康缺陷有因果关系。它在流行病学和经济学领域都得到了相当多的实证支持，但到目前为止，它还没有被整合到人类衰老和长寿的生命周期理论中。本研究表明，基于老年学中开发的虚弱指数的健康缺陷模型产生与假设一致的休克放大。为了讨论从受孕到死亡的整个生命周期中的人类健康，我们发展了子宫内和儿童期的个体发育和健康理论，将其与成人衰老的健康缺陷模型相结合，并讨论了生命早期冲击的传递到晚年健康缺陷积累。