ABSTRACT

Over the past 20 years, humankind has encountered three severe coronavirus outbreaks. Currently ongoing, COVID-19 (coronavirus disease 2019) was declared a pandemic due to its massive impact on global health and the economy. Numerous scientists are working to identify efficacious therapeutic agents for COVID-19, although treatment ability has yet to be demonstrated. The SUMO (small ubiquitin-like modifier) system has diverse roles in viral manipulation, but the function of SUMO in coronaviruses is still unknown. The objective of this review article is to present recently published data suggesting contributions of the host SUMO system to coronavirus infection. These findings underscore the potential of SUMO as a novel target for anti-coronavirus therapy, and the need for a deeper understanding of coronavirus pathology to prepare and prevail against the current and emerging coronavirus outbreaks.

摘要

在过去的 20 年中，人类遭遇了 3 次严重的冠状病毒疫情。目前正在进行的 COVID-19（2019 年冠状病毒病）因其对全球健康和经济的巨大影响而被宣布为大流行病。许多科学家正在努力寻找 COVID-19 的有效治疗剂，尽管治疗能力尚未得到证实。SUMO（小泛素样修饰剂）系统在病毒操纵中具有多种作用，但 SUMO 在冠状病毒中的功能仍然未知。这篇评论文章的目的是介绍最近发表的数据，这些数据表明宿主 SUMO 系统对冠状病毒感染的贡献。这些发现强调了 SUMO 作为抗冠状病毒治疗新靶点的潜力，