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Hybrid mesoporous nanostructured scaffolds as dielectric biosimilar restorative materials
Bio-Medical Materials and Engineering ( IF 1.0 ) Pub Date : 2021-03-23 , DOI: 10.3233/bme-201118
Berta Rivas-Mundiña 1 , Zulema Vargas-Osorio 2 , Susana Yáñez-Vilar 2 , Marta Rizk 3 , Yolanda Piñeiro 2 , Mario Pérez-Sayáns 1, 4 , José Rivas 2
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BACKGROUND:The intricate structure of natural materials is in correspondence with its highly complex functional behaviour. The health of teeth depends, in a complex way, on a heterogeneous arrangement of soft and hard porous tissues that allow for an adequate flow of minerals and oxygen to providecontinuous restoration. Although restorative materials, used in clinics, have been evolving from the silver amalgams to actual inorganic fillers, their structural and textural properties are scarcely biomimetic, hindering the functional recovery of the tissue. OBJECTIVE:The objective of this work is to compare and test the hybrid mesoporous silica-based scaffolds as candidates for dentine restoration applications. METHODS:In this work, we present the development and the physical properties study of biocompatible hybrid mesoporous nanostructured scaffolds with a chemically versatile surface and biosimilar architecture. We test their textural (BET) and dielectric permittivity (ac impedance) properties. RESULTS:These materials, with textural and dielectric properties similar to dentine and large availability for the payload of therapeutic agents, are promising candidates as functional restorative materials, suitable for impedance characterization techniques in dental studies. CONCLUSIONS:Structural, textural, morphological characterization and electrical properties of hybrid mesoporous show a large degree of similarity to natural dentin samples.

中文翻译:

混合介孔纳米结构支架作为介电生物仿制药修复材料

背景:天然材料的复杂结构与其高度复杂的功能行为是一致的。牙齿的健康以一种复杂的方式取决于软质和硬质多孔组织的异质排列,这些组织允许矿物质和氧气的充足流动以提供持续的修复。尽管用于临床的修复材料已经从银汞合金演变为真正的无机填料,但它们的结构和质地特性几乎无法仿生,阻碍了组织的功能恢复。目的:这项工作的目的是比较和测试混合介孔二氧化硅基支架作为牙本质修复应用的候选材料。方法:在这项工作中,我们介绍了具有化学通用表面和生物仿制药结构的生物相容性混合介孔纳米结构支架的开发和物理性质研究。我们测试了它们的纹理 (BET) 和介电常数(交流阻抗)特性。结果:这些材料具有与牙本质相似的质地和介电特性,并且治疗剂的有效载荷很大,是有希望的候选功能性修复材料,适用于牙科研究中的阻抗表征技术。结论:混合介孔的结构、质地、形态特征和电学性质与天然牙本质样品有很大程度的相似性。我们测试了它们的纹理 (BET) 和介电常数(交流阻抗)特性。结果:这些材料具有与牙本质相似的质地和介电特性,并且治疗剂的有效载荷很大,是有希望的候选功能性修复材料,适用于牙科研究中的阻抗表征技术。结论:混合介孔的结构、质地、形态特征和电学性质与天然牙本质样品有很大程度的相似性。我们测试了它们的纹理 (BET) 和介电常数(交流阻抗)特性。结果:这些材料具有与牙本质相似的质地和介电特性,并且治疗剂的有效载荷很大,是有希望的候选功能性修复材料,适用于牙科研究中的阻抗表征技术。结论:混合介孔的结构、质地、形态特征和电学性质与天然牙本质样品有很大程度的相似性。
更新日期:2021-03-27
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