BACKGROUND:Bone volume augmentation is a routine technique used in oral implantology and periodontology. Advances in the surgical techniques and the biomaterials field have allowed a greater accessibility to these treatments. Nevertheless, dehiscence and fenestrations incidence during dental implant procedures are still common in patients with bone loss. OBJECTIVE:The main objective is to evaluate in a pilot experimental study the biological response to mesoporous silica (MS) hybrid scaffolds and its regenerative capacity in different formulations. METHODS:Two defects per rabbit tibia were performed (one for control and other for test) and the biomaterials tested in this study have been used to fill the bone defects, prepared in two different formulations (3D hybrid scaffolds or powdered material, in 100% pure MS form, or 50% MS with 50% hydroxyapatite (HA). Euthanasia was performed 4 months after surgery for bone histopathological study and radiographic images were acquired by computerized microtomography. RESULTS:Results showed that radiographically and histopathologically pure MS formulations lead to a lower biological response, e.g when formulated with HA, the osteogenic response in terms of osteoconduction was greater. CONCLUSIONS:We observed tolerance and lack of toxicity of the MS and HA, without registering any type of local or systemic allergic reaction.

中文翻译：

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介孔二氧化硅及其与羟基磷灰石结合对兔骨缺损再生的影响：初步研究

背景：骨量增加是口腔种植学和牙周病学中使用的常规技术。外科技术和生物材料领域的进步使这些治疗方法更容易获得。尽管如此，牙种植体手术过程中的开裂和开窗在骨质流失患者中仍然很常见。目的：主要目的是在初步实验研究中评估介孔二氧化硅 (MS) 混合支架的生物反应及其在不同配方中的再生能力。方法：对每个兔胫骨进行两个缺损（一个用于对照，另一个用于测试），本研究中测试的生物材料已用于填充骨缺损，以两种不同的配方（3D 混合支架或粉状材料，100%纯 MS 形式，或 50% MS 与 50% 羟基磷灰石 (HA)。安乐死在手术后 4 个月进行骨组织病理学研究，并通过计算机显微断层扫描获得放射图像。结果：结果表明，放射学和组织病理学纯 MS 制剂导致较低的生物反应，例如，当与 HA 一起配制时，骨传导方面的成骨反应更大。结论：我们观察到 MS 和 HA 的耐受性和无毒性，未发现任何类型的局部或全身过敏反应。g 当与 HA 一起配制时，在骨传导方面的成骨反应更大。结论：我们观察到 MS 和 HA 的耐受性和无毒性，未发现任何类型的局部或全身过敏反应。g 当与 HA 一起配制时，在骨传导方面的成骨反应更大。结论：我们观察到 MS 和 HA 的耐受性和无毒性，未发现任何类型的局部或全身过敏反应。