Preterm premature rupture of membranes is associated with 30% of all preterm births. The weakening of amniotic membranes is associated with an increase in matrix metallopeptidases (MMPs) along with a decrease in their inhibitors, tissue inhibitor metallopeptidases (TIMPs). Additionally, granulocyte-macrophage colony-stimulating factor (GM-CSF) has been shown to weaken fetal membranes in-vitro. We hypothesize pregnant mice treated with GM-CSF lead to increased MMPs:TIMPs resulting in membrane rupture and preterm birth.

中文翻译：

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粒细胞-巨噬细胞集落刺激因子在小鼠模型中引发羊膜破裂和早产

早产胎膜早破与 30% 的早产有关。羊膜的减弱与基质金属肽酶 (MMP) 的增加以及它们的抑制剂组织抑制剂金属肽酶 (TIMP) 的减少有关。此外，已显示粒细胞-巨噬细胞集落刺激因子 (GM-CSF) 在体外削弱胎膜。我们假设用 GM-CSF 治疗的怀孕小鼠会导致 MMPs：TIMPs 增加，从而导致膜破裂和早产。