Antibacterial materials are widely used in various fields, and Poly(hexamethylene guanidine hydrochloride) (PHMG) is an effective broad-spectrum antibacterial agent with great potential in preparing antibacterial materials. Therefore, in this work, type B PHMG was prepared and incorporated into anionic waterborne polyurethane (AWPU) and cationic waterborne polyurethane (CWPU) following three incorporation ways (post-, in-situ and pre- methods). Subsequently, films were obtained by solvent-casting and their thermal, mechanical, contact angle and antibacterial properties were systematic studied. The results shown that owing to the strong electronic attraction between PHMG and AWPU, the stable PHMG modified AWPU (PAWPU) dispersions were obtained by pre-method only. However, PAWPU films has no antibacterial activity. In addition, the stable PHMG modified CWPU (PCWPU) dispersions were obtained by pre-method and in-situ-method. Unlike PAWPU films, PCWPU films exhibited excellent antibacterial activity, the antibacterial efficiency of PCWPU containing 2 wt% PHMG against E. coli is 98.4 % after 1 h incubation. Simultaneously, PHMG not leached from PCWPU films.

抗菌材料广泛应用于各个领域，聚六亚甲基胍盐酸盐（PHMG）是一种有效的广谱抗菌剂，具有制备抗菌材料的巨大潜力。因此，在这项工作中，制备了B型PHMG，并通过三种掺入方式（后置，原位和预处理方法）将其掺入阴离子型水性聚氨酯（AWPU）和阳离子型水性聚氨酯（CWPU）中。随后，通过溶剂浇铸获得了薄膜，并对其热，机械，接触角和抗菌性能进行了系统研究。结果表明，由于PHMG和AWPU之间的强电子吸引力，仅通过预方法即可获得稳定的PHMG改性AWPU（PAWPU）分散体。但是，PAWPU膜没有抗菌活性。此外，原位方法。与PAWPU膜不同，PCWPU膜表现出优异的抗菌活性，孵育1 h后，含有2 wt％PHMG的PCWPU对大肠杆菌的抗菌效率为98.4％。同时，PHMG没有从PCWPU膜中浸出。