Objective

To evaluate the thermal antinociceptive effects of a high-concentration formulation of buprenorphine alone or followed by hydromorphone in conscious cats.

Study design

Randomized, blinded, placebo-controlled crossover study design.

Animals

A total of six purpose-bred, adult female ovariohysterectomized Domestic Short Hair cats.

Methods

Cats were allocated into three treatments each consisting of two injections, subcutaneous then intravenous (IV) administration, 2 hours apart: treatment SS, two injections of 0.9% saline; treatment BS, buprenorphine (0.24 mg kg^–1, 1.8 mg mL^–1) and saline; and treatment BH, buprenorphine (0.24 mg kg^–1) and hydromorphone (0.1 mg kg^–1). Skin temperature (ST) and thermal threshold (TT) were recorded before (baseline) and for 24 hours following first injection. TT data were analyzed using mixed linear models and a Benjamini–Hochberg sequential adjustment procedure (p < 0.05).

Results

There were no significant differences among treatments for baseline ST and TT values, treatment SS over time and between treatments BS and BH. Compared with baseline, TT was significantly increased at all time points in treatments BH and BS except at 2 hours in treatment BS. TT was significantly higher than SS at 3–18 hours and 4–12 hours for treatments BS and BH, respectively. Maximal increases in TT were 47.5 °C at 2 hours, 53.9 °C at 3 hours and 52.4 °C at 6 hours in treatments SS, BS and BH, respectively.

Conclusions and clinical relevance

Administration of IV hydromorphone following high-concentration buprenorphine provided no additional antinociception and decreased the duration of effect when compared with high-concentration buprenorphine alone. Alternative analgesics should be considered if additional analgesia is required after administration of high-concentration buprenorphine.

中文翻译：

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高浓度丁丙诺啡单独或随后使用氢吗啡酮对清醒猫的热镇痛作用

客观的

评估高浓度丁丙诺啡单独或随后使用氢吗啡酮对清醒猫的热镇痛作用。

学习规划

随机、盲法、安慰剂对照的交叉研究设计。

动物

总共六只专门饲养的成年雌性卵巢子宫切除的家养短毛猫。

方法

猫被分配到三个治疗组，每个治疗组包括两次注射，皮下注射，然后静脉注射 (IV)，间隔 2 小时：治疗 SS，两次注射 0.9% 盐水；治疗 BS、丁丙诺啡（0.24 mg kg ^–1、1.8 mg mL ^–1）和生理盐水；和治疗 BH、丁丙诺啡 (0.24 mg kg ^–1 ) 和氢吗啡酮 (0.1 mg kg ^–1 )。在第一次注射之前（基线）和之后 24 小时记录皮肤温度 (ST) 和热阈值 (TT)。使用混合线性模型和 Benjamini-Hochberg 顺序调整程序分析 TT 数据（p < 0.05）。

结果

在基线 ST 和 TT 值、随时间的治疗 SS 以及治疗 BS 和 BH 之间，治疗之间没有显着差异。与基线相比，除 BS 治疗 2 小时外，BH 和 BS 治疗的所有时间点 TT 均显着增加。对于 BS 和 BH 处理，TT 分别在 3-18 小时和 4-12 小时显着高于 SS。在 SS、BS 和 BH 处理中，TT 的最大增加分别为 2 小时时 47.5 °C、3 小时时 53.9 °C 和 6 小时时 52.4 °C。

结论和临床相关性

与单独使用高浓度丁丙诺啡相比，在高浓度丁丙诺啡后静脉注射氢吗啡酮不提供额外的镇痛作用，并缩短了作用持续时间。如果在使用高浓度丁丙诺啡后需要额外镇痛，应考虑替代镇痛药。