ABSTRACT

Background

Cerebral palsy (CP) possesses bilateral sensory-motor cortical excitability alterations. In past studies, researchers have applied unilateral anodal transcranial direct stimulation (tDCS) with inconsistent findings.

Objective

Examining the effects of treadmill training with either unilateral or bilateral anodal tDCS stimulation on brain activities, gait, and body functions of children with CP.

Design

Randomized-clinical-trial.

Participants

Eighty children with CP will be allocated into: treadmill/bilateral-tDCS, treadmill/unilateral-tDCS, treadmill/sham-tDCS, and treadmill groups. Additional 20 neurotypical children will be recruited for comparison.

Intervention

Planned intervention will implement ten-sessions of treadmill training (50% of maximum-ground speed) either with unilateral-tDCS over left sensory-motor, or bilateral-tDCS over left/right sensory-motor areas. Brain activities, gait, body functions, and participation will be assessed at pre-intervention, post-intervention, and at one-month follow-up.

Result and Discussion

This study would contribute to extant findings on the use of tDCS stimulation in children with CP and to our understanding of the appropriateness of the planned outcome measures.

中文翻译：

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双侧阳极经颅直流电刺激与跑步机训练对脑瘫儿童大脑活动、步态功能、参与水平和享受的影响：随机对照试验方案

摘要

背景

脑性麻痹 (CP) 具有双侧感觉运动皮层兴奋性改变。在过去的研究中，研究人员应用了单侧阳极经颅直接刺激 (tDCS)，但结果不一致。

客观的

检查跑步机训练与单侧或双侧阳极 tDCS 刺激对 CP 儿童的大脑活动、步态和身体功能的影响。

设计

随机临床试验。

参与者

80 名患有 CP 的儿童将被分配到：跑步机/双侧-tDCS、跑步机/单侧-tDCS、跑步机/假-tDCS 和跑步机组。将招募另外 20 名神经型儿童进行比较。

干涉

计划的干预将实施十次跑步机训练（最大地面速度的 50%），在左感觉运动区域使用单侧 tDCS，或在左/右感觉运动区域使用双侧 tDCS。大脑活动、步态、身体功能和参与将在干预前、干预后和一个月的随访中进行评估。

结果与讨论

本研究将有助于对 CP 儿童使用 tDCS 刺激的现有发现以及我们对计划结果测量的适当性的理解。