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An immunologically friendly classification of non-peptidic ligands
Database: The Journal of Biological Databases and Curation ( IF 3.4 ) Pub Date : 2021-03-03 , DOI: 10.1093/database/baab014
Lindy Edwards 1 , Rebecca Jackson 1, 2 , James A Overton 1, 2 , Randi Vita 1 , Nina Blazeska 1 , Bjoern Peters 1, 3 , Alessandro Sette 1, 3
Affiliation  

The Immune Epitope Database (IEDB) freely provides experimental data regarding immune epitopes to the scientific public. The main users of the IEDB are immunologists who can easily use our web interface to search for peptidic epitopes via their simple single-letter codes. For example, ‘A’ stands for ‘alanine’. Similarly, users can easily navigate the IEDB’s simplified NCBI taxonomy hierarchy to locate proteins from specific organisms. However, some epitopes are non-peptidic, such as carbohydrates, lipids, chemicals and drugs, and it is more challenging to consistently name them and search upon, making access to their data more problematic for immunologists. Therefore, we set out to improve access to non-peptidic epitope data in the IEDB through the simplification of the non-peptidic hierarchy used in our search interfaces. Here, we present these efforts and their outcomes. Database URL: http://www.iedb.org/

中文翻译:

非肽配体的免疫学友好分类

免疫表位数据库 (IEDB) 免费向科学公众提供有关免疫表位的实验数据。IEDB 的主要用户是免疫学家,他们可以通过简单的单字母代码轻松使用我们的网络界面搜索肽表位。例如,“A”代表“丙氨酸”。同样,用户可以轻松导航 IEDB 的简化 NCBI 分类层次结构,以定位来自特定生物的蛋白质。然而,一些表位是非肽的,例如碳水化合物、脂质、化学物质和药物,并且始终如一地命名和搜索它们更具挑战性,这使得免疫学家访问它们的数据更加困难。因此,我们着手通过简化我们搜索界面中使用的非肽层次结构来改进对 IEDB 中非肽表位数据的访问。这里,我们介绍了这些努力及其成果。数据库网址:http://www.iedb.org/
更新日期:2021-03-03
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