Objective

COVID-19 has substantial morbidity and mortality. We studied whether hospitalized patients with COVID-19 and chronic inflammatory diseases experienced worse outcomes compared to patients hospitalized with COVID-19 without chronic inflammatory diseases.

Methods

Danish nationwide registers were used to establish a cohort of hospitalized patients with COVID-19 and inflammatory bowel diseases (IBD), rheumatoid arthritis (RA), spondyloarthropathy (SpA), or psoriatic arthritis (PsA) (exposed), and a control cohort without these diseases (unexposed) between March 1, 2020, and October 31, 2020. We compared median length of hospital stay, used median regression models to estimate crude and adjusted differences. When estimating crude and adjusted odds ratio (OR) for continuous positive airway pressure (CPAP) and mechanical ventilation, in-hospital death, 14-day and 30-day mortality, we used logistic regression models.

Results

We identified 132 patients with COVID-19 and IBD, RA, SpA, or PsA, and 2811 unexposed admitted to hospital with COVID-19. There were no differences between exposed and unexposed regarding length of hospital stay (6.8 days vs. 5.5 days), need for mechanical ventilation (7.6% vs. 9.4%), or CPAP (11.4% vs. 8.8%). Adjusted OR for in-hospital death was 0.71 (95% CI 0.42–1.22), death after 14-days 0.70 (95% CI 0.42–1.16), and death after 30-days 0.68 (95% CI 0.41–1.13).

Conclusion

Hospitalized patients with COVID-19 and chronic inflammatory diseases did not have statistically significant increased length of hospital stay, had same need for mechanical ventilation, and CPAP. Mortality was similar in hospitalized patients with COVID-19 and chronic inflammatory diseases, compared to patients hospitalized with COVID-19 and no chronic inflammatory diseases.

中文翻译：

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患有慢性炎症性疾病的住院患者中 COVID-19 的结果。丹麦基于人口的国家登记研究

 客观的

COVID-19 具有很高的发病率和死亡率。我们研究了患有 COVID-19 和慢性炎症性疾病的住院患者是否比患有慢性炎症性疾病的 COVID-19 住院患者的预后更差。

 方法

丹麦全国登记册用于建立一组患有 COVID-19 并伴有炎症性肠病 (IBD)、类风湿性关节炎 (RA)、脊柱关节病 (SpA) 或银屑病关节炎 (PsA)（暴露）的住院患者，以及一组未患有炎症性肠病 (IBD) 的对照队列。 2020年3月1日至2020年10月31日之间这些疾病（未暴露）。我们比较了中位住院时间，使用中位回归模型来估计粗略和调整后的差异。在估计持续气道正压通气 (CPAP) 和机械通气的粗略和调整优势比 (OR)、院内死亡、14 天和 30 天死亡率时，我们使用逻辑回归模型。

 结果

我们确定了 132 名患有 COVID-19 并患有 IBD、RA、SpA 或 PsA 的患者，以及 2811 名未接触过的患有 COVID-19 入院的患者。暴露和未暴露之间在住院时间（6.8 天 vs. 5.5 天）、机械通气需求（7.6% vs. 9.4%）或 CPAP（11.4% vs. 8.8%）方面没有差异。院内死亡的调整后 OR 为 0.71 (95% CI 0.42–1.22)，14 天后死亡为 0.70 (95% CI 0.42–1.16)，30 天后死亡为 0.68 (95% CI 0.41–1.13)。

 结论

患有 COVID-19 和慢性炎症性疾病的住院患者的住院时间没有统计学上显着增加，对机械通气和 CPAP 的需求相同。与患有 COVID-19 且没有慢性炎症性疾病的住院患者相比，患有 COVID-19 和慢性炎症性疾病的住院患者的死亡率相似。