In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- and micro-particles including biological cells with the advantages of label-free, high sensitivity and accuracy. In this letter, we introduce a novel tilted-angle SAW devices to optimise the acoustic pressure inside a microchannel for cancer-cell manipulation. The SAW generation and acoustic radiation force are improved by seamlessly patterning electrodes in the space surrounding the microchannel. Comparisons between this novel SAW device and a conventional device show a 32% enhanced separation efficiency while the input power, manufacturing cost and fabrication effort remain the same. Effective separation of HeLa cancer cells from peripheral blood mononuclear cells is demonstrated. This novel SAW device has the advantages in minimizing device power consumption, lowering component footprint and increasing device density.

中文翻译：

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用于癌细胞操纵的增强的倾斜角声流体芯片

近年来，表面声波（SAW）装置在处理包括生物细胞在内的纳米和微粒方面具有​​无标签，高灵敏度和准确性的优势，已显示出巨大的潜力和越来越多的应用。在这封信中，我们介绍了一种新颖的倾斜角声表面波器件，可以优化微通道内部的声压，以用于癌细胞的操纵。通过在微通道周围的空间中对电极进行无缝构图，可以改善SAW的产生和声辐射力。这种新型声表面波器件与常规器件的比较表明，分离效率提高了32％，而输入功率，制造成本和制造工作却保持不变。证明了从外周血单核细胞中有效分离HeLa癌细胞。