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Delayed cortical processing of auditory stimuli in children with autism spectrum disorder: A meta-analysis of electrophysiological studies
Brain and Cognition ( IF 2.5 ) Pub Date : 2021-03-26 , DOI: 10.1016/j.bandc.2021.105709
Anna R. Jorgensen , Andrew J.O. Whitehouse , Allison M. Fox , Murray T. Maybery

Several researchers have hypothesised that individuals with Autism Spectrum Disorder (ASD) show encoding delays in their obligatory event-related potentials (ERPs)/ event-related fields (ERFs) for low-level auditory information compared to neurotypical (NT) samples. However, empirical research has yielded varied findings, such as low-level auditory processing in ASD samples being unimpaired, superior, or impaired compared to NT samples. Diverse outcomes have also been reported for studies investigating ASD-NT differences in functional lateralisation of delays. The lack of consistency across studies has prevented a comprehensive understanding of the overall effects in the autistic population. Therefore, this meta-analysis compared long-latency ERPs and ERFs produced by autistic and NT individuals to non-linguistic auditory stimuli to test, firstly, the robustness of auditory processing differences and, secondly, whether these differences are observed in one or both hemispheres. Nine articles meeting the inclusion criteria were included in the meta-analysis. Meta-analytic results indicated that autistic individuals demonstrate bilaterally delayed P1/ M50 peaks and lateralised delays in the right but not left hemisphere N1/ M100 peak. These results further inform our understanding of auditory processing and lateralisation across the autism spectrum.



中文翻译:

自闭症谱系障碍儿童听觉刺激的皮质延迟处理:电生理研究的荟萃分析

一些研究人员假设,自闭症谱系障碍(ASD)的个体与低水平听觉信息相比,在其低水平听觉信息的强制性事件相关电位(ERP)/事件相关领域(ERF)中显示出编码延迟。然而,经验研究得出了各种发现,例如与NT样品相比,ASD样品的低水平听觉处理没有受到损害,优越或受损。研究延缓功能性侧向方面的ASD-NT差异的研究也已报道了多种结果。各项研究之间缺乏一致性,导致无法全面了解自闭症人群的总体影响。因此,这项荟萃分析将自闭症患者和NT患者产生的长时延ERP和ERF与非语言听觉刺激进行了比较,首先,听觉处理差异的鲁棒性,其次,是否在一个或两个半球中观察到这些差异。荟萃分析包括9篇符合纳入标准的文章。荟萃分析结果表明,自闭症患者的双侧P1 / M50峰出现双侧延迟,而右半球N1 / M100峰则出现双侧延迟,而左半球N1 / M100峰则没有。这些结果进一步说明了我们对自闭症谱系中听觉处理和偏侧化的理解。荟萃分析结果表明,自闭症患者的双侧P1 / M50峰出现双侧延迟,而右半球N1 / M100峰则出现双侧延迟,而左半球N1 / M100峰则没有。这些结果进一步说明了我们对自闭症谱系中听觉处理和偏侧化的理解。荟萃分析结果表明,自闭症患者的双侧P1 / M50峰出现双侧延迟,而右半球N1 / M100峰则出现双侧延迟,而左半球N1 / M100峰则没有。这些结果进一步说明了我们对自闭症谱系中听觉处理和偏侧化的理解。

更新日期:2021-03-26
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