当前位置: X-MOL 学术Part. Fibre Toxicol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Chronic exposure to PM2.5 aggravates SLE manifestations in lupus-prone mice
Particle and Fibre Toxicology ( IF 10 ) Pub Date : 2021-03-25 , DOI: 10.1186/s12989-021-00407-0
Victor Yuji Yariwake 1 , Janaína Iannicelli Torres 1 , Amandda Rakell Peixoto Dos Santos 2 , Sarah Cristina Ferreira Freitas 3 , Kátia De Angelis 3 , Sylvia Costa Lima Farhat 1, 4 , Niels Olsen Saraiva Câmara 2, 5 , Mariana Matera Veras 1
Affiliation  

Air pollution causes negative impacts on health. Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse clinical manifestations and multifactorial etiology. Recent studies suggest that air pollution can trigger SLE and induce disease activity. However, this association has not been deeply investigated. Thus, the aim of this study was to evaluate whether exposure to fine particulate matter (PM2.5) exacerbates SLE manifestations, focusing on renal complications, in a lupus-prone animal model. Female NZBWF1 mice were exposed daily to 600 μg/m3 of inhaled concentrated ambient particles (CAP) or filtered air (FA). Survival rate, body weight, weight of organs (kidney, spleen, thymus, liver and heart), blood cell count, proteinuria, kidney stereology, renal histopathology, gene expression and oxidative stress were analyzed. Female NZBW mice exposed to CAP showed decreased survival, increased circulating neutrophils, early onset of proteinuria and increased kidney weight with renal cortex enlargement when compared to NZBW mice exposed to FA. This work shows that air pollution aggravates some SLE manifestations in lupus-prone mice. These results reinforce the need of reducing air pollutant levels in order to promote a better quality of life for individuals diagnosed with SLE.

中文翻译:

长期暴露于 PM2.5 会加重狼疮小鼠的 SLE 表现

空气污染对健康造成负面影响。系统性红斑狼疮(SLE)是一种自身免疫性疾病,具有多种临床表现和多因素病因。最近的研究表明,空气污染可引发 SLE 并诱发疾病活动。然而,这种关联并没有被深入研究。因此,本研究的目的是评估暴露于细颗粒物 (PM2.5) 是否会加剧狼疮易发动物模型中的 SLE 表现,重点是肾脏并发症。雌性 NZBWF1 小鼠每天暴露于 600 μg/m3 的吸入浓缩环境颗粒 (CAP) 或过滤空气 (FA)。分析了存活率、体重、器官重量(肾、脾、胸腺、肝脏和心脏)、血细胞计数、蛋白尿、肾脏体视学、肾脏组织病理学、基因表达和氧化应激。与暴露于 FA 的 NZBW 小鼠相比,暴露于 CAP 的雌性 NZBW 小鼠显示存活率降低、循环中性粒细胞增加、蛋白尿早发和肾重量增加以及肾皮质增大。这项工作表明,空气污染加剧了狼疮小鼠的某些 SLE 表现。这些结果强化了降低空气污染物水平的必要性,以提高被诊断为 SLE 的个体的生活质量。
更新日期:2021-03-25
down
wechat
bug