Abstract

Glycopolymers are multifunctional bio-mimetic supramolecules that can emulate the functions of glycopeptides. Entitled to molecular recognition, these molecules appertain to amplify the original bio-molecular interactions with lectins. It is ubiquitous that glycopolymers offer the potential to be explored for targeted drug delivery and tumor cell treatment, unfolding new dawn in tissue engineering. Moreover, their self-assembly trait is advantageous in medical adhesives and implants. This review abridges gap, associating physiology of bio-recognition, glyco-polymeric integration, and chemical changes that follow. Techniques for synthesis of these artificial linkers, their properties, characterization analysis, and methodologies to improve binding rates and bioactivity of glycopolymers are also enlisted.

摘要

糖聚合物是多功能仿生超分子，可以模拟糖肽的功能。这些分子有权进行分子识别，属于放大与凝集素的原始生物分子相互作用。糖聚合物为靶向药物递送和肿瘤细胞治疗提供了探索的潜力，这为组织工程开辟了新的曙光，这一点无处不在。此外，它们的自组装特性在医用粘合剂和植入物方面具有优势。这篇综述缩小了差距，将生物识别的生理学、糖聚合物整合和随后的化学变化联系起来。还列出了用于合成这些人工接头的技术、它们的特性、表征分析以及提高糖聚合物结合率和生物活性的方法。