Orthogonal experiments were used to simulate the enrofloxacin (ENR) elimination dynamic in deeper water of aquaculture. Two factors at values common in fishery water (temperature of 20°C, 25°C, and 30°C; pH of 5, 7, and 9) were studied. The degradation of ENR in the nine treatment groups ranged from 44.7 to 80.1%. Variance analysis indicated that pH had a strong impact on the elimination of ENR, while temperature changes showed little effect. The ENR removal rate was highest at a combination of 25°C and pH 5. The optimal conditions of eliminating ENR were performed for exploring the generation of ciprofloxacin (CIP), which indicated that higher ENR concentrations led to the production of greater amounts of CIP. The half-time of ENR was increased 2.02-times in the ENR concentrations increasing from 20 to 2000 ng/mL. This study could increase our understanding of the behaviors of ENR and CIP during the aquaculture process.

正交试验用于模拟深水养殖水中恩诺沙星（ENR）的消除动态。研究了在渔业用水中常见的两个因素（温度为20°C，25°C和30°C； pH为5、7和9）。在9个治疗组中，ENR的降解率为44.7％至80.1％。方差分析表明，pH值对消除ENR的影响很大，而温度变化几乎没有影响。在25°C和pH 5的结合下，ENR去除率最高。为消除环丙沙星（CIP）的生成，进行了消除ENR的最佳条件，这表明较高的ENR浓度导致产生更多的CIP。 。当ENR浓度从20 ng / mL增加到2000 ng / mL时，ENR的半衰期增加了2.02倍。