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Liver type 1 innate lymphoid cells develop locally via an interferon-γ–dependent loop
Science ( IF 44.7 ) Pub Date : 2021-03-26 , DOI: 10.1126/science.aba4177
Lu Bai 1, 2 , Margaux Vienne 3 , Ling Tang 1, 2 , Yann Kerdiles 3 , Marion Etiennot 3 , Bertrand Escalière 3 , Justine Galluso 3 , Haiming Wei 1, 2, 4 , Rui Sun 1, 2, 4 , Eric Vivier 3, 5, 6 , Hui Peng 1, 2, 4 , Zhigang Tian 1, 2, 4
Affiliation  

The pathways that lead to the development of tissue-resident lymphocytes, including liver type 1 innate lymphoid cells (ILC1s), remain unclear. We show here that the adult mouse liver contains LinSca-1+Mac-1+ hematopoietic stem cells derived from the fetal liver. This population includes LinCD122+CD49a+ progenitors that can generate liver ILC1s but not conventional natural killer cells. Interferon-γ (IFN-γ) production by the liver ILC1s themselves promotes the development of these cells in situ, through effects on their IFN-γR+ liver progenitors. Thus, an IFN-γ–dependent loop drives liver ILC1 development in situ, highlighting the contribution of extramedullary hematopoiesis to regional immune composition within the liver.



中文翻译:


肝脏 1 型先天淋巴细胞通过干扰素 γ 依赖性环局部发育



导致组织驻留淋巴细胞(包括肝脏 1 型先天淋巴细胞 (ILC1))发育的途径仍不清楚。我们在此表明​​,成年小鼠肝脏含有 Lin Sca-1 + Mac-1 +来自胎儿肝脏的造血干细胞。该群体包括 Lin CD122 + CD49a +祖细胞,可以产生肝脏 ILC1,但不能产生传统的自然杀伤细胞。肝脏 ILC1 本身产生的干扰素-γ (IFN-γ) 通过影响 IFN-γR +肝脏祖细胞,促进这些细胞原位发育。因此,IFN-γ依赖性环路驱动肝脏ILC1原位发育,突出了髓外造血对肝脏内区域免疫组成的贡献。

更新日期:2021-03-25
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