Shedding light on the mechanisms that underlie a durable response to immunotherapy, a recent study evaluating long-term survivors of melanoma treated with immunotherapy finds that tumor-associated T cell clonotypes are sustained over years and persist as expanded, cytokine IFN-γ–expressing resident memory T cells in the skin, with effector memory counterparts in the blood.

中文翻译：

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黑色素瘤反应性 T 细胞驻扎


最近一项评估接受免疫疗法治疗的黑色素瘤长期幸存者的研究揭示了免疫疗法持久反应的机制，发现肿瘤相关 T 细胞克隆型可以持续多年，并且以表达细胞因子 IFN-γ 的扩展形式持续存在皮肤中的记忆 T 细胞，以及血液中的效应记忆对应物。