Shedding light on the mechanisms that underlie a durable response to immunotherapy, a recent study evaluating long-term survivors of melanoma treated with immunotherapy finds that tumor-associated T cell clonotypes are sustained over years and persist as expanded, cytokine IFN-γ–expressing resident memory T cells in the skin, with effector memory counterparts in the blood.

中文翻译：

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黑色素瘤反应性 T 细胞占据住所

最近一项评估免疫疗法治疗的黑色素瘤长期幸存者的研究揭示了对免疫疗法产生持久反应的机制，发现肿瘤相关的 T 细胞克隆型持续多年，并随着细胞因子 IFN-γ 表达的扩展而持续存在。皮肤中的记忆 T 细胞，以及血液中的效应记忆对应物。