The systemic spread of tumor cells is the ultimate cause of the majority of deaths from cancer, yet few successful therapeutic strategies have emerged to specifically target metastasis. Here we discuss recent advances in our understanding of tumor-intrinsic pathways driving metastatic colonization and therapeutic resistance, as well as immune-activating strategies to target metastatic disease. We focus on therapeutically exploitable mechanisms, promising strategies in preclinical and clinical development, and emerging areas with potential to become innovative treatments.

中文翻译：

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治疗转移的新兴策略

肿瘤细胞的全身扩散是大多数癌症死亡的最终原因，但针对转移的成功治疗策略却很少出现。在这里，我们讨论了我们对驱动转移定植和治疗耐药的肿瘤内在途径的理解的最新进展，以及针对转移性疾病的免疫激活策略。我们专注于治疗上可利用的机制、临床前和临床开发中有前途的策略以及有潜力成为创新疗法的新兴领域。