Contact lens-related complications are common, affecting around one third of wearers, although most are mild and easily managed. Contact lenses have well-defined anatomical and physiological effects on the ocular surface and can result in other consequences due to the presence of a biologically active material. A contact lens interacts with the tear film, ocular surface, skin, endogenous and environmental microorganisms, components of care solutions and other antigens which may result in disease specific to contact lens wear, such as metabolic or hypersensitivity disorders. Contact lens wear may also modify the epidemiology or pathophysiology of recognised conditions, such as papillary conjunctivitis or microbial keratitis. Wearers may also present with intercurrent disease, meaning concomitant or pre-existing conditions unrelated to contact lens wear, such as allergic eye disease or blepharitis, which may complicate the diagnosis and management of contact lens-related disease.

Complications can be grouped into corneal infection (microbial keratitis), corneal inflammation (sterile keratitis), metabolic conditions (epithelial: microcysts, vacuoles, bullae, tight lens syndrome, epithelial oedema; stromal: superficial and deep neovascularisation, stromal oedema [striae/folds], endothelial: blebs, polymegethism/ pleomorphism), mechanical (corneal abrasion, corneal erosion, lens binding, warpage/refractive error changes; superior epithelial arcuate lesion, mucin balls, conjunctival epithelial flaps, ptosis, discomfort), toxic and allergic disorders (papillary conjunctivitis, solution-induced corneal staining, incomplete neutralisation of peroxide, Limbal Stem Cell Deficiency), tear resurfacing disorders/dry eye (contact lens-induced dry eye, Meibomian gland dysfunction, lid wiper epitheliopathy, lid parallel conjunctival folds, inferior closure stain, 3 and 9 o'clock stain, dellen, dimple veil) or contact lens discomfort. This report summarises the best available evidence for the classification, epidemiology, pathophysiology, management and prevention of contact lens-related complications in addition to presenting strategies for optimising contact lens wear.

与隐形眼镜相关的并发症很常见，影响约三分之一的佩戴者，但大多数都是轻微的且易于管理。隐形眼镜对眼表具有明确的解剖学和生理学影响，并且由于生物活性材料的存在可能导致其他后果。隐形眼镜会与泪膜、眼表、皮肤、内源性和环境微生物、护理液成分和其他抗原相互作用，这些抗原可能导致隐形眼镜佩戴特有的疾病，例如代谢或过敏性疾病。佩戴隐形眼镜还可能改变公认疾病的流行病学或病理生理学，例如乳头状结膜炎或微生物角膜炎。佩戴者也可能出现并发疾病，

眼睑平行结膜皱襞、劣质闭合染色、3 点钟和 9 点钟染色、dellen、酒窝面纱）或隐形眼镜不适。本报告总结了隐形眼镜相关并发症的分类、流行病学、病理生理学、管理和预防的最佳可用证据，此外还介绍了优化隐形眼镜佩戴的策略。