Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases and aging itself. Therefore, the targeted elimination of senescent cells may be beneficial for long-term human health in general. In this review, we summarize three key areas of recent research into the clearance of senescent cells, including senolysis via senolytic drugs, immune-based senescent cell clearance, and neutralization of the senescence-associated secretory phenotype (SASP). Therapeutic strategies for the targeted clearance of senescent cells are being developed at a rapid pace, with some already undergoing clinical trials in humans. In the future, advances in the targeted clearance of senescent cells will undoubtedly yield further beneficial ways to improve human health during aging and increase human longevity.

细胞衰老是由于累积的DNA损伤和随着时间的流逝蛋白变性丧失而导致不可逆的细胞周期停滞的发生。衰老细胞会导致与年龄有关的疾病和自身衰老。因此，有针对性地消除衰老细胞通常可能对长期人类健康有益。在这篇综述中，我们总结了有关衰老细胞清除的最新研究的三个关键领域，包括通过senolytic药物进行的衰老，基于免疫的衰老细胞清除以及与衰老相关的分泌表型（SASP）的中和。靶向清除衰老细胞的治疗策略正在迅速发展，其中一些已经在人体中进行了临床试验。将来，