Wavefront shaping holds great potential for high-resolution imaging or light delivery either through or deep inside living tissue. However, one of the biggest barriers that must be overcome to unleash the full potential of wavefront shaping for practical biomedical applications is the fact that wavefront shaping, especially based on iterative feedback, requires lengthy measurements to obtain useful correction of the output wavefront. As biological tissues are inherently dynamic, the short decorrelation time sets a limit on the achievable wavefront shaping enhancement. Here we show that for wavefront shaping in thin anisotropic scattering media such as biological tissues, we can optimize the wavefront shaping quality by simply limiting the numerical aperture (NA) of the incident wavefront. Using the same number of controlled modes, and therefore the same wavefront measurement time, we demonstrate that the wavefront shaped focus peak to background ratio can be increased by a factor of 2.1 while the energy delivery throughput can be increased by a factor of 8.9 through 710 µm thick brain tissue by just limiting the incident NA.

中文翻译：

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通过薄的各向异性散射介质限制入射NA以实现有效的波前整形

波前整形在通过活体组织或深入活组织内部进行高分辨率成像或光传输方面具有巨大的潜力。但是，要释放出波前整形在实际生物医学应用中的全部潜力，必须克服的最大障碍之一是以下事实：波前整形，尤其是基于迭代反馈的波前整形，需要进行漫长的测量才能获得输出波前的有用校正。由于生物组织固有地是动态的，因此较短的去相关时间限制了可实现的波前成形增强的极限。在这里，我们表明，对于薄薄的各向异性散射介质（例如生物组织）中的波前成形，我们可以通过简单地限制入射波前的数值孔径（NA）来优化波前成形质量。使用相同数量的受控模式