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Nanotechnology for inflammatory bowel disease management: Detection, imaging and treatment
Sensing and Bio-Sensing Research ( IF 5.4 ) Pub Date : 2021-03-23 , DOI: 10.1016/j.sbsr.2021.100417
Mahmood Barani , Abbas Rahdar , Saman Sargazi , Mohammad Sadegh Amiri , Preetam Kumar Sharma , Nikhil Bhalla

Inflammatory bowel disease (IBD) is a group of intestinal disorders which cause prolonged digestive tract inflammation. The early diagnosis of IBD through the detection of its biomarkers (including tumor necrosis factor alpha, C-reactive protein, cytokines and microRNAs) and imaging agents is a challenge. Nanotechnology enabled biosensors and enhanced image contrasting chemicals for diagnosis offer promises for an affordable, early and reliable confirmation of the disease and type thereof. Moreover, engineered nanoparticles (NPs) can also be used to deliver active drug agents directly to the region of inflammation. Major advantages of the targeted drug delivery are low dosage drug requirement due to localized/guided delivery and minimal side effects to other organs by the drug. Here, we present a mini review about different engineered nanostructures (Au NPs, Graphene, Quantum dots, inorganic NPs, etc.) and plant-based nanoparticles for the detection, imaging and treatment of IBD.



中文翻译:

用于炎症性肠病管理的纳米技术:检测,成像和治疗

炎症性肠病(IBD)是一组肠道疾病,会引起长时间的消化道炎症。通过检测其生物标志物(包括肿瘤坏死因子α,C反应蛋白,细胞因子和微小RNA)和显像剂,对IBD进行早期诊断是一项挑战。纳米技术使生物传感器和增强的图像对比化学试剂可用于诊断,为疾病及其类型的可负担,早期和可靠的确认提供了希望。此外,工程化的纳米颗粒(NP)也可用于将活性药物直接递送到炎症区域。靶向药物递送的主要优点是由于局部/引导递送而导致的低剂量药物需求以及该药物对其他器官的最小副作用。这里,)和用于IBD的检测,成像和治疗的植物基纳米颗粒。

更新日期:2021-03-30
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