Musca domestica is a global insect-pest of human beings and animal agriculture. Pyriproxyfen, a juvenile hormone analog, has shown its potential for effective management of M. domestica. However, lethal and sublethal effects of pyriproxyfen on biological traits and demographic growth parameters of M. domestica are still unknown. The present study investigated the effects of lethal and sublethal concentrations on different biological traits of M. domestica for two generations i.e., exposed parents (F0) and their offspring (F1). Concentration-response bioassays revealed that concentrations of pyriproxyfen that caused 50% (LC₅₀), 25% (LC₂₅), 10% (LC₁₀) and 2% (LC₂) mortality of M. domestica were estimated as 0.12, 0.06, 0.03 and 0.01 μg/g, respectively. In the F0 generation, exposure of 3^rd instar larvae to these concentrations resulted in a reduced pupation rate, lengthened pupal stage duration, light weight pupae and reduction in adult emergence in a concentration-dependent manner. In the case of F1 generation, similar trend was observed for pupation rate, pupal stage duration, and total developmental period (i.e., egg to adult); however, pupal weight was affected at LC₁₀, LC₂₅, LC₅₀ levels, and adult emergence at only LC₂₅ and LC₅₀ levels. The values of demographic growth parameters, analyzed through age-stage, two-sex life table theory, were significantly decreased at all the levels of pyriproxyfen compared with control. This study highlights that pyriproxyfen has the potential to suppress the population of M. domestica through its lethal and sublethal effects and presents an empirical basis from which to consider management decisions for chemical control in the field.

家蝇是人类和动物农业的全球害虫。吡罗昔芬是一种少年激素类似物，已显示出有效管理家蝇的潜力。然而，在生物学特性和人口增长参数吡丙醚的致死和亚致死效应家蝇还是一个未知数。本研究调查了不同的生物学特性和致死亚致死剂量的影响家蝇两代即暴露父母（F0）和他们的后代（F1）。浓度响应生物测定表明，吡ip草酚的浓度引起50％（LC ₅₀），25％（LC ₂₅），10％（LC ₁₀）和2％（LC₂）死亡率家蝇被估计为0.12，0.06，0.03和0.01微克/克。在F0代，3的曝光^第三龄幼虫到这些浓度导致降低的化蛹率，加长蛹期的持续时间，重量轻的蛹和降低以浓度依赖的方式成虫羽化。在F1代的情况下，化p率，p期持续时间和总发育期（即卵到成年）的趋势相似。然而，幼仔体重在LC ₁₀，LC ₂₅，LC ₅₀水平受到影响，而成年出苗仅在LC ₂₅和LC ₅₀受到影响水平。通过年龄，两性寿命表理论分析的人口增长参数值在所有吡ip昔芬水平上均较对照组显着降低。这项研究强调的是吡丙醚具有抑制人口的潜在家蝇通过它的致死和亚致死效应，并提出从考虑在现场化学品控制管理决策的经验基础。