ABSTRACT

Introduction: As the pathogen that caused the first influenza virus pandemic in this century, the swine-origin A(H1N1) pdm09 influenza virus has caused continuous harm to human public health. The evolution of hemagglutinin protein glycosylation sites, including the increase in number and positional changes, is an important way for influenza viruses to escape host immune pressure. Based on the traditional influenza virus molecular monitoring, special attention should be paid to the influence of glycosylation evolution on the biological characteristics of virus antigenicity, transmission and pathogenicity. The epidemiological significance of glycosylation mutants should be analyzed as a predictive tool for early warning of new outbreaks and pandemics, as well as the design of vaccines and drug targets.

Areas covered: We review on the evolutionary characteristics of glycosylation on the HA protein of the A(H1N1)pdm09 influenza virus in the last ten years.

Expert opinion: We discuss the crucial impact of evolutionary glycosylation on the biological characteristics of the virus and the host immune responses, summarize studies revealing different roles of glycosylation play during host adaptation. Although these studies show the significance of glycosylation evolution in host-virus interaction, much remains to be discovered about the mechanism.

摘要

简介： 猪源甲型H1N1 pdm09流感病毒作为引发本世纪首例流感病毒大流行的病原体，对人类公共卫生造成持续危害。血凝素蛋白糖基化位点的进化，包括数量的增加和位置的变化，是流感病毒逃避宿主免疫压力的重要途径。在传统流感病毒分子监测的基础上，应特别关注糖基化进化对病毒抗原性、传播性和致病性等生物学特性的影响。糖基化突变体的流行病学意义应作为新暴发和大流行的早期预警以及疫苗和药物靶点设计的预测工具进行分析。

涵盖的领域：我们回顾了过去十年来 A(H1N1)pdm09 流感病毒 HA 蛋白糖基化的进化特征。

专家意见：我们讨论了进化糖基化对病毒生物学特性和宿主免疫反应的关键影响，总结了揭示糖基化在宿主适应过程中发挥不同作用的研究。尽管这些研究表明了糖基化进化在宿主-病毒相互作用中的重要性，但关于该机制仍有许多待发现。