The solubility of kaempferol monohydrate (KFM) in five mono-solvents (ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol) and three binary solvents (ethanol + water, 1-propanol + water, 2-propanol + water) was measured by gravimetric method from 283.15 K to 323.15 K at the pressure of 0.1 MPa. It is concluded that solubility of KFM is a function of temperature and solvent composition. Statistical method was used to analyze the impact of physicochemical parameters of solvents on solubility of KFM, indicating that comprehensive factors, such as the hydrogen bonding donor capacity and cohesive energy density would influence on solubility of KFM. In addition, the COSMO-RS model was used to explore the effects of solvent-solute interactions on solubility of KFM. Further, the solubility data was correlated by the modified Apelblat equation, λh equation, and van't Hoff equation, in which the modified Apelblat equation showed the best correlation result. In the final, the apparent thermodynamic properties (${\Delta }_{\text{sol}}{H}^0$,${\Delta }_{\text{sol}}{G}^0$, ${\Delta }_{\text{sol}}{S}^0$) of KFM were derived through the van't Hoff equation, demonstrating the dissolution process of KFM in the selected solvents was endothermic. We hope the solubility of KFM determined in this work provides data can support for its further purification.

山emp酚一水合物（KFM）在五种单溶剂（乙醇，1-丙醇，2-丙醇，1-丁醇，2-丁醇）和三种二元溶剂（乙醇+水，1-丙醇+水，2-丙醇）中的溶解度通过重量法在0.1 MPa的压力下从283.15 K到323.15 K测量+ +水）。结论是，KFM的溶解度是温度和溶剂组成的函数。采用统计方法分析了溶剂的理化参数对KFM溶解度的影响，表明氢键供体容量和内聚能密度等综合因素对KFM的溶解度有影响。此外，使用COSMO-RS模型探索溶剂-溶质相互作用对KFM溶解度的影响。此外，溶解度数据通过修改后的Apelblat方程进行关联，λh方程和van't Hoff方程，其中经修改的Apelblat方程显示出最佳的相关结果。最后，表观热力学性质（${\Delta }_{\text{溶胶}}{H}^0$，${\Delta }_{\text{溶胶}}{G}^0$， ${\Delta }_{\text{溶胶}}{\mathrm{小号}}^0$KFM是通过van't Hoff方程得出的，表明KFM在所选溶剂中的溶解过程是吸热的。我们希望在这项工作中确定的KFM溶解度提供数据可以支持其进一步纯化。