As in other fields of medicine, development of new medications for management of neuropathic pain has been difficult since preclinical rodent models do not necessarily translate to the clinics. Aside from ongoing pain with burning or shock-like qualities, neuropathic pain is often characterized by pain hypersensitivity (hyperalgesia and allodynia), most often towards mechanical stimuli, reflecting sensitization of neural transmission.

中文翻译：

---

中枢敏化的人类替代模型：批判性审查和实践指南

与其他医学领域一样，开发用于治疗神经性疼痛的新药物一直很困难，因为临床前啮齿动物模型不一定会转化为临床。除了具有灼烧感或休克样特性的持续疼痛外，神经性疼痛的特征通常是痛觉过敏（痛觉过敏和异常性疼痛），最常见的是机械刺激，反映了神经传递的敏感性。