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Conservation of endangered species through somatic cell nuclear transfer (SCNT)
Conservation Genetics Resources ( IF 0.9 ) Pub Date : 2021-03-23 , DOI: 10.1007/s12686-021-01204-9
Ambreen Iqbal , Jiang Ping , Shaokat Ali , Gao Zhen , Jin Zi Kang , Pan Zi Yi , Lu Huixian , Zhao Zhihui

Currently, the conservation of biodiversity is a pressing issue due to the extinction and endangerment of many species. There are multiple reasons for the extinction or endangerment of species including anthropogenic (poaching, hunting, and deforestation) and natural causes (forest fire, invasion of non-local species, climate change, and global warming). The somatic cell nuclear transfer (SCNT) is an emerging tactic, which requires the nucleus from a donor somatic cell, which is transferred to the enucleated oocyte in vitro, for the conservation of biodiversity, especially related to the wildlife which is gradually decreasing with the fear of extinction. Somatic cell nuclear transfer has a broad spectrum of potential applications, including the rescue of endangered species, the resurrection of extinct species, the production of transgenic animals, drug production, and regenerative medicine. Reproductive cloning of animals by SCNT can also offer permanent gene editing, genetic modification, and gene derives for the production of species adaptive to their native habitats and the destruction of unwanted invasive species. The overall potential of this technique has not been explored yet, probably due to its limitations. In this review, we discussed cloning through SCNT, the preservation of endangered species through SCNT, and the use of modern genetical concepts in SCNT for the preservation of biodiversity.



中文翻译:

通过体细胞核移植(SCNT)保护濒危物种

当前,由于许多物种的灭绝和濒危,生物多样性的保护是一个紧迫的问题。物种灭绝或濒危的原因有多种,包括人为的(偷猎,狩猎和毁林)和自然原因(森林火灾,非本地物种的入侵,气候变化和全球变暖)。体细胞核转移(SCNT)是一种新兴的策略,它需要将供体体细胞的核从体外转移到去核卵母细胞中,以保护生物多样性,尤其是与野生生物有关的生物体,随着这种生物体的逐渐减少。害怕灭绝。体细胞核转移具有广泛的潜在应用,包括挽救濒危物种,复活灭绝物种,生产转基因动物,药品生产和再生医学。通过SCNT进行的动物生殖克隆还可以提供永久性的基因编辑,遗传修饰和基因衍生,以生产适应其原生栖息地的物种并破坏有害的入侵物种。可能由于其局限性,尚未对该技术的整体潜力进行探讨。在这篇综述中,我们讨论了通过SCNT进行克隆,通过SCNT保护濒危物种以及在SCNT中使用现代遗传概念来保护生物多样性。可能由于其局限性,尚未对该技术的整体潜力进行探讨。在这篇综述中,我们讨论了通过SCNT进行克隆,通过SCNT保护濒危物种以及在SCNT中使用现代遗传概念来保护生物多样性。可能由于其局限性,尚未对该技术的整体潜力进行探讨。在这篇综述中,我们讨论了通过SCNT进行克隆,通过SCNT保护濒危物种以及在SCNT中使用现代遗传概念来保护生物多样性。

更新日期:2021-03-23
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