Pharmaceuticals represent a group of emerging contaminants. The short-term effect (3 and 7 days) of warfarin (1 and 10 mg L⁻¹), dexamethasone (0.392 and 3.92 mg L⁻¹) and imidazole (0.013 and 0.13 mg L⁻¹) exposure was evaluated on mussels (Mytilus galloprovincialis). Total antioxidant status, glutathione reductase, glutathione peroxidase (GPx) and superoxide dismutase enzyme activities, and the expression of genes involved in the xenobiotic response (ATP binding cassette subfamily B member 1 (abcb1) and several nuclear receptor family J (nr1j) isoforms), were evaluated. All nr1j isoforms are suggested to be the xenobiotic receptor orthologs of the NR1I family. All drugs increased GPx activity and altered the expression of particular nr1j isoforms. Dexamethasone exposure also decreased abcb1 expression. These findings raised some concerns regarding the release of these pharmaceuticals into the aquatic environment. Thus, further studies might be needed to perform an accurate environmental risk assessment of these 3 poorly studied drugs.

药品代表了一组新兴污染物。在贻贝上评估了华法林（1和10 mg L ^-1），地塞米松（0.392和3.92 mg L ^-1）和咪唑（0.013和0.13 mg L ^-1）的短期作用（3天和7天）。鸡没食子菌）。总抗氧化剂状态，谷胱甘肽还原酶，谷胱甘肽过氧化物酶（GPx）和超氧化物歧化酶活性，以及​​参与异源生物应答的基因的表达（ATP结合盒亚家族B成员1（abcb1）和几个核受体家族J（nr1j）亚型） ，进行了评估。全部nr1j异构体被认为是NR1I家族的异种受体直向同源物。所有药物均增加GPx活性并改变特定nr1j同工型的表达。地塞米松暴露也降低了abcb1表达。这些发现引起了人们对这些药物向水生环境释放的担忧。因此，可能需要进行进一步的研究才能对这3种药物研究不足的药物进行准确的环境风险评估。