A natural compound with the algicidal effect was isolated from the culture medium of Aspergillus sp. SCSIOW2 and was identified as malformin C, which was based on the data of ¹H-NMR, ¹³C-NMR, and ESI-MS. Malformin C exhibited dose-dependent algicidal activities against two strains of noxious red tide algae, Akashiwo sanguinea and Chattonella marina. The activity against A. sanguinea was stronger than that against C. marina (the algicidal activity of 58 and 36% at 50 μM treatment for 2 h, respectively). Morphology changes including perforation, plasmolysis, and fragmentation of algal cells were observed. Malformin C induced a significant increase in ROS level, caused the damage of SOD activity, and led to the massive generation of MDA contents in algae cells. To our knowledge, this is the first report of the cyclic peptide described as an algicidal compound against HABs.

从曲霉菌的培养基中分离出具有杀藻作用的天然化合物。基于¹ H-NMR，¹³ C-NMR和ESI-MS的数据，将SCSIOW2鉴定为MalforminC 。malformin C对两种有毒的赤潮藻类Akashiwo sanguinea和Chattonella marina菌株显示出剂量依赖性的杀藻活性。对血红曲霉的抗药性强于对滨海假单胞菌的抗药性（在50μM处理2 h时的杀藻活性分别为58％和36％）。观察到形态学变化，包括穿孔，胞质溶解和藻类细胞破碎。malformin C导致ROS水平显着增加，导致SOD活性受损，并导致藻类细胞中大量产生MDA含量。据我们所知，这是描述为抗HAB的杀藻化合物的环状肽的首次报道。