Genetic association between interleukin‐10 gene rs1518111 and rs3021094 polymorphisms and risk of type 1 diabetes and diabetic nephropathy in Egyptian children and adolescents,Pediatric Diabetes

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Genetic association between interleukin‐10 gene rs1518111 and rs3021094 polymorphisms and risk of type 1 diabetes and diabetic nephropathy in Egyptian children and adolescents
Pediatric Diabetes ( IF 3.9 ) Pub Date : 2021-03-21 , DOI: 10.1111/pedi.13201
Rania Mostafa El Helaly ₁ , Rasha Rizk Elzehery ₁ , Ola Ali El-Emam ₁ , Huda Ahmed El Domiaty ₂ , Wesam Reda Elbohy ₃ , Hadil Mohamed Aboelenin ₄ , Nanees Abdel-Badie Salem ₄

Affiliation

Genetic and environmental factors have been implicated in etiopathogenesis and progression of type 1 diabetes mellitus (T1DM) and diabetic nephropathy (DN). Genetic association between interleukin‐10 (IL‐10) single nucleotide polymorphisms (SNPs) with T2DM and DN was recently established. We aimed to explore the potential genetic risk of IL‐10 gene rs1518111 and rs3021094 SNPs in susceptibility to T1DM and DN.

中文翻译：

白细胞介素 10 基因 rs1518111 和 rs3021094 多态性与埃及儿童和青少年 1 型糖尿病和糖尿病肾病风险之间的遗传关联

遗传和环境因素与 1 型糖尿病 (T1DM) 和糖尿病肾病 (DN) 的发病机制和进展有关。最近确定了白细胞介素-10 (IL-10) 单核苷酸多态性 (SNP) 与 T2DM 和 DN 之间的遗传关联。我们旨在探索 IL-10 基因 rs1518111 和 rs3021094 SNP 在 T1DM 和 DN 易感性中的潜在遗传风险。

更新日期：2021-05-04

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