Angiogenesis and osteogenesis are coupled. However, the cellular and molecular regulation of these processes remains to be further investigated. Both tissues have recently been recognized as endocrine organs, which has stimulated research interest in the screening and functional identification of novel paracrine factors from both tissues. This review aims to elaborate on the novelty and significance of endocrine regulatory loops between bone and the vasculature. In addition, research progress related to the bone vasculature, vessel-related skeletal diseases, pathological conditions, and angiogenesis-targeted therapeutic strategies are also summarized. With respect to future perspectives, new techniques such as single-cell sequencing, which can be used to show the cellular diversity and plasticity of both tissues, are facilitating progress in this field. Moreover, extracellular vesicle-mediated nuclear acid communication deserves further investigation. In conclusion, a deeper understanding of the cellular and molecular regulation of angiogenesis and osteogenesis coupling may offer an opportunity to identify new therapeutic targets.

血管生成和骨生成是耦合的。然而，这些过程的细胞和分子调控仍有待进一步研究。这两种组织最近都被认为是内分泌器官，这激发了人们对这两种组织中新型旁分泌因子的筛选和功能鉴定的研究兴趣。本综述旨在详细阐述骨与脉管系统之间内分泌调节环路的新颖性和意义。此外，还总结了骨脉管系统、血管相关骨骼疾病、病理状况以及血管生成靶向治疗策略等方面的研究进展。展望未来，单细胞测序等新技术可用于显示两种组织的细胞多样性和可塑性，正在促进该领域的进展。此外，细胞外囊泡介导的核酸通讯值得进一步研究。总之，对血管生成和成骨耦合的细胞和分子调节的更深入了解可能为识别新的治疗靶点提供机会。