Abstract

Among all central nervous diseases, malignant glioma is a crucial part that deserves more attention since high fatality and disability rate. There are several therapeutic strategies applied to the treatment of malignant glioma, especially certain chemotherapy-related treatments. However, the existence of the blood–brain barrier (BBB) seriously hinders the strategy's progress, so how to escape from the barriers is a fascinating question. Herein, we comprehensively discussed the details of malignant glioma and the BBB's functional morphology and summarised several routes bypassing the BBB. Additionally, since possessing excellent properties for drug delivery, we provided an insight into various promising natural polymeric materials and highlighted their applications in the treatment of malignant glioma.

摘要

在所有中枢神经系统疾病中，恶性胶质瘤是一个重要的部位，致死率和致残率高，值得更多关注。有几种治疗策略适用于恶性神经胶质瘤的治疗，尤其是某些与化疗相关的治疗。然而，血脑屏障（BBB）的存在严重阻碍了该策略的进展，如何摆脱血脑屏障是一个引人入胜的问题。在此，我们全面讨论了恶性胶质瘤的细节和BBB的功能形态，并总结了绕过BBB的几种途径。此外，由于具有出色的药物输送特性，我们深入了解了各种有前途的天然聚合物材料，并强调了它们在治疗恶性胶质瘤中的应用。