Abstract

Objective

During acute relapses of multiple sclerosis (MS), physical symptoms attract utmost care. However, cognitive impairment may constitute an substantial part of a new relapse. In this study, we evaluated the cognitive status of MS patients during acute relapses.

Materials and methods

We enrolled 35 definite MS patients and 21 healthy subjects. Neuropsychometric tests and the event-related potential, P300 were administered to the MS patients before corticosteroid treatment, and 3 months later. The control subjects were tested only once.

Results

The differences between the scores of the Timed 25-Foot Walk test, the Brief Repeatable Battery subtests (10/36 SPART, SDMT, SRT, SRT-LTM) in the relapse and remission phases were statistically significant (p = .005, p = .007, p = .05, p = .029, p = .001, respectively). The latencies of P300 waves during the relapses were significantly prolonged than the ones in the remission and the controls’ (p = .004, p < .001, respectively).

Conclusions

In this study, we observed a significant involvement of visual-spatial perception, remote memory, and recall, as well as P300 latencies in acute relapses. The inclusion of cognitive assessment during a relapse can provide accurate information on cognitive status for future treatment modalities.

中文翻译：

---

急性复发中的认知：心理测量评估及其与事件相关电位的相关性，多发性硬化症中的 P300

摘要

客观的

在多发性硬化症 (MS) 急性复发期间，身体症状引起了极大的关注。然而，认知障碍可能构成新复发的重要部分。在这项研究中，我们评估了 MS 患者在急性复发期间的认知状态。

材料和方法

我们招募了 35 名确诊 MS 患者和 21 名健康受试者。在皮质类固醇治疗前和 3 个月后，对 MS 患者进行神经心理测量测试和事件相关电位 P300。对照组只测试一次。

结果

定时 25 英尺步行测试、Brief Repeatable Battery 子测试（10/36 SPART、SDMT、SRT、SRT-LTM）在复发和缓解阶段的得分差异具有统计学意义（p  = .005，p  = .007、p  = .05、p  = .029、p  = .001）。复发期间 P300 波的潜伏期比缓解期和对照组的潜伏期显着延长（分别为p  = .004，p  < .001）。

结论

在这项研究中，我们观察到视觉空间感知、远程记忆和回忆以及 P300 潜伏期在急性复发中的显着参与。在复发期间纳入认知评估可以为未来的治疗方式提供有关认知状态的准确信息。