The usefulness of eye-tracking tasks as potential biomarkers for motor or cognitive disease burden in Parkinson’s disease (PD) has been subject of debate for many years. Several studies suggest that the performance in the antisaccade task may be altered in patients with PD and associated with motor disease severity or executive dysfunction. In this meta-analysis, random effects models were used to synthesize the existing evidence on antisaccade error rates and latency in PD. Furthermore, meta-regressions were performed to assess the role of motor and cognitive disease severity, dopaminergic medication and methodological factors. Additionally, the impact of acute levodopa administration and activation of deep brain stimulation was evaluated in two separate sub-analyses.

This meta-analysis confirms that antisaccade latency and error rate are significantly increased in PD. Disease duration, Unified Parkinson’s disease rating scale score and Hoehn and Yahr stage mediate the effect of PD on antisaccade latency with higher motor burden being associated with increased antisaccade latency.

Acute administration of levodopa had no significant effects on antisaccade performance in a small number of eligible studies. Deep brain stimulation in the subthalamic nucleus, on the other hand, may alter the speed accuracy trade-off supporting an increase of impulsivity following deep brain stimulation in PD.

According to the results of the meta-analysis, antisaccade latency may provide a potential marker for disease severity and progression in PD which needs further confirmation in longitudinal studies.

多年来，眼动追踪任务作为帕金森病 (PD) 运动或认知疾病负担的潜在生物标志物的有用性一直是争论的主题。几项研究表明，在 PD 患者中，antisaccade 任务的表现可能会发生改变，并且与运动疾病的严重程度或执行功能障碍有关。在这项荟萃分析中，随机效应模型用于综合现有的关于 PD 中反跳动错误率和潜伏期的证据。此外，进行元回归以评估运动和认知疾病严重程度、多巴胺能药物和方法学因素的作用。此外，在两个单独的子分析中评估了急性左旋多巴给药和脑深部刺激激活的影响。

该荟萃分析证实，PD 中的反跳动潜伏期和错误率显着增加。疾病持续时间、统一帕金森病评定量表评分和 Hoehn 和 Yahr 分期介导 PD 对反眼跳潜伏期的影响，较高的运动负荷与反眼跳潜伏期增加有关。

在少数符合条件的研究中，左旋多巴的急性给药对抗眼跳性能没有显着影响。另一方面，丘脑底核深部脑刺激可能会改变速度准确性权衡，支持在 PD 中进行深部脑刺激后冲动性的增加。

根据荟萃分析的结果，antisaccade 潜伏期可能为 PD 疾病严重程度和进展提供潜在标志物，这需要在纵向研究中进一步确认。