This study develops a novel model of a consumer-resource system with mobility included, in order to explain a novel experiment of competition between two breast cancer cell lines grown in 3D in vitro spheroid culture. The model reproduces observed differences in monoculture, such as overshoot phenomena and final size. It also explains both theoretically and through simulation the inevitable triumph of the same cell line in co-culture, independent of initial conditions. The mobility of one cell line (MDA-MB-231) is required to explain both the success and the rapidity with which that species dominates the population and drives the other species (MCF-7) to extinction. It is shown that mobility directly interferes with the other species and that the cost of that mobility is in resource usage rate.

本研究开发了一种包含移动性的消费者资源系统的新模型，以解释在 3D体外球体培养中生长的两种乳腺癌细胞系之间的竞争的新实验。该模型再现了单一栽培中观察到的差异，例如超调现象和最终尺寸。它还从理论上和通过模拟解释了相同细胞系在共培养中不可避免的胜利，独立于初始条件。需要一种细胞系 (MDA-MB-231) 的流动性来解释该物种在种群中占主导地位并驱使其他物种 (MCF-7) 灭绝的成功和速度。结果表明，流动性直接干扰其他物种，流动性的成本是资源使用率。