Severe acute respiratory syndrome–associated coronavirus 2 has caused a global public health crisis with high rates of infection and mortality. Treatment and prevention approaches include vaccine development, the design of small-molecule antiviral drugs, and macromolecular neutralizing antibodies. Polymers have been designed for effective virus inhibition and as antiviral drug delivery carriers. This review summarizes recent progress and provides a perspective on polymer-based approaches for the treatment and prevention of coronavirus infection. These polymer-based partners include polyanion/polycations, dendritic polymers, macromolecular prodrugs, and polymeric drug delivery systems that have the potential to significantly improve the efficacy of antiviral therapeutics.

严重急性呼吸综合征相关冠状病毒 2 已导致全球公共卫生危机，感染率和死亡率都很高。治疗和预防方法包括疫苗开发、小分子抗病毒药物设计和大分子中和抗体。聚合物已被设计用于有效抑制病毒并用作抗病毒药物递送载体。本综述总结了最近的进展，并就基于聚合物的方法治疗和预防冠状病毒感染提供了观点。这些基于聚合物的伙伴包括聚阴离子/聚阳离子、树枝状聚合物、大分子前药和聚合物药物递送系统，它们有可能显着提高抗病毒治疗的功效。