Background

The aim of this study was to examine the association between hypertensive disorders of pregnancy (HDP) and behavioural outcomes in offspring at five time-points.

Methods

We used maternal-reported data from the Millennium Cohort Study. Data on HDP were collected when children were 9-months. Data on behavioural outcomes were collected at age 3, 5, 7, 11 and 14years using the Strengths and Difficulties Questionnaire (SDQ). Multivariate logistic regression analysis examined a HDP-behavioural difficulties relationship, using validated SDQ cut-off points. Multilevel models with linear splines examined the association between HDP and repeated measures of SDQ.

Results

18,274 singleton children were included in the study at baseline, Multivariate logistic regression suggested HDP was not significantly associated with SDQ domain cut-off points at ages 3, 7 and 11years. At age 5years, HDP was associated with a 40% increased odds of behavioural difficulties based on total SDQ(≥17) (OR:1.40, 95% CI:1.03,1.91). HDP was associated with a 43% increased odds of Peer Problem difficulties at age 5 (OR:1.43, 95% CI:1.10,1.86), and a 28% increased odds of Peer Problem difficulties(≥4) at age 14 (OR:1.28, 95% CI:1.02,1.61). In the linear spline model, mean SDQ score was higher at each time-point in those exposed to HDP, although did not always reach statistical significance.

Limitations

Data on different classifications of HDP were unavailable; therefore, we could not examine the effect of gestational hypertension and preeclampsia separately.

Conclusions

While we did not find strong evidence of associations between HDP and behavioural outcomes overall, some associations between HDP and behavioural difficulties did persist at age 5 and 14years.

中文翻译：

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子孙后代的妊娠高血压病和行为结果：千年队列研究的发现

背景

这项研究的目的是在五个时间点检查妊娠高血压疾病（HDP）与后代行为预后之间的关系。

方法

我们使用了来自千年队列研究的母亲报告的数据。在儿童9个月大时收集HDP数据。使用优势和困难调查表（SDQ）收集了3、5、7、11和14岁时行为表现的数据。多元逻辑回归分析使用经验证的SDQ临界点检验了HDP与行为困难之间的关系。具有线性样条的多级模型检查了HDP和SDQ的重复测量之间的关联。

结果

基线时有18274名单身儿童被纳入研究。多因素Logistic回归分析表明，HDP与3、7和11岁时的SDQ域截止点没有显着相关。根据总SDQ（≥17），HDP在5岁时与行为困难几率增加40％（OR：1.40，95％CI：1.03,1.91）。HDP与5岁时出现同伴问题的几率增加43％（OR：1.43，95％CI：1.10,1.86），14岁时出现同伴问题的几率（≥4）增加28％（OR： 1.28，95％CI：1.02,1.61）。在线性样条模型中，HDD暴露者在每个时间点的平均SDQ得分均较高，尽管并不总是具有统计学意义。

局限性

无法获得有关HDP不同分类的数据；因此，我们无法单独检查妊娠高血压和先兆子痫的影响。

结论

虽然我们没有找到有力的证据表明HDP与行为结果之间存在关联，但HDP与行为困难之间的某些关联在5岁和14岁时就一直存在。