In orthopaedic and trauma surgery, implant-associated infections are increasingly treated with local application of antibiotics, which allows a high local drug concentration to be reached without eliciting systematic adverse effects. While ceftriaxone is a widely used antibiotic agent that has been shown to be effective against musculoskeletal infections, high local concentrations may harm the surrounding tissue. This study investigates the acute and subacute cytotoxicity of increasing ceftriaxone concentrations as well as their influence on the osteogenic differentiation of human bone progenitor cells.

中文翻译：

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头孢曲松钠对人骨细胞生存能力和体外矿化潜力的影响与浓度和时间有关。

在整形外科和创伤外科手术中，越来越多地通过局部应用抗生素治疗与植入物相关的感染，这可以在不引起系统性副作用的情况下达到较高的局部药物浓度。虽然头孢曲松是一种广泛使用的抗生素，已被证明对肌肉骨骼感染有效，但高局部浓度可能会损害周围的组织。这项研究调查了增加的头孢曲松钠浓度的急性和亚急性细胞毒性，以及它们对人骨祖细胞成骨分化的影响。