Vitamin and homocysteine (Hcy) alternations have been associated with psychiatric disorders. The aim of this meta-analysis was to assess the association of serum vitamin and Hcy levels with obsessive-compulsive disorder (OCD). Following PRISMA protocol, we used the databases including Scopus, PubMed, Google Scholar, and Web of Science with no time restriction. Data were pooled using a random-effects model and/or fixed-effects model to estimate the standard mean difference (SMD) for evaluation of the strength of association analyses. Our data showed a significant reduction in vitamin B₁₂ (SMD = −0.58, 95% CI = −1.08 to −0.08, p = 0.02, I² = 65%; p_{heterogeneity} = 0.06), vitamin E (SMD = −0.89, 95% CI = −1.23 to −0.56, p #x3c; 0.00001, I² = 23%; p_{heterogeneity} = 0.26), and vitamin C (SMD = −1.40, 95% CI = −2.44 to −0.36, p = 0.008, I² = 92%; p_{heterogeneity} #x3c; 0.0001) in OCD patients. In addition, the findings showed significantly higher levels of Hcy (SMD = 1.11, 95% CI = [0.48, 1.75], p = 0.0006, I² = 73%; p_h = 0.02) in patients compared to controls. Also, our data showed that vitamin B₉ and D levels are not associated with OCD (vitamin B₉: SMD = −0.23, 95% CI = −1.01 to 0.55, p = 0.56, I² = 88%; p_{heterogeneity} #x3c; 0.0001; vitamin D: SMD = −0.63, 95% CI = −1.41 to 0.15, p = 0.11, I² = 88%; p_{heterogeneity} = 0.0002). Our findings support significant impacts of Hcy and vitamin B₁₂, E, and C levels in OCD pathogenesis. This will be important for prevention and treatment of OCD. However, further studies are recommended to elucidate more accurate conclusions.
Neuropsychobiology

中文翻译：

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强迫症的血清维生素和同型半胱氨酸水平：系统评价和荟萃分析

维生素和同型半胱氨酸 (Hcy) 交替与精神疾病有关。这项荟萃分析的目的是评估血清维生素和 Hcy 水平与强迫症 (OCD) 的关系。按照 PRISMA 协议，我们使用了 Scopus、PubMed、Google Scholar 和 Web of Science 等数据库，没有时间限制。使用随机效应模型和/或固定效应模型汇总数据，以估计标准平均差 (SMD) 以评估关联分析的强度。_{我们的数据显示维生素 B 12}显着减少（SMD = -0.58，95% CI = -1.08 至 -0.08，p = 0.02，I ² = 65%；p_异质性= 0.06)、维生素 E (SMD = -0.89, 95% CI = -1.23 到 -0.56, p #x3c; 0.00001, I ² = 23%; p_异质性= 0.26) 和维生素 C (SMD = -1.40, 95 % CI = -2.44 至 -0.36，p = 0.008，I ² = 92%；p_异质性#x3c；0.0001) 在 OCD 患者中。此外，研究结果显示，与对照组相比，患者的 Hcy 水平显着升高（SMD = 1.11, 95% CI = [0.48, 1.75], p = 0.0006, I ² = 73%; p _h = 0.02）。此外，我们的数据显示维生素 B ₉和 D 水平与强迫症无关（维生素 B ₉: SMD = -0.23, 95% CI = -1.01 至 0.55, p = 0.56, I ² = 88%; p_异质性#x3c; 0.0001; 维生素 D：SMD = -0.63，95% CI = -1.41 至 0.15，p = 0.11，I ² = 88%；p_异质性= 0.0002)。_{我们的研究结果支持 Hcy 和维生素 B 12}、E 和 C 水平在强迫症发病机制中的显着影响。这对于预防和治疗强迫症很重要。但是，建议进一步研究以阐明更准确的结论。
神经心理生物学